Sorbonne Paris Nord University, INSERM U1153, INRAE U1125, CNAM, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center, Centre of Research in Epidemiology and Statistics, Université Paris Cité, Paris, France; NACRe Network-Nutrition and Cancer Research Network, Jouy-en-Josas, France.
INSERM U1016, Mucosal microbiota in chronic inflammatory diseases, CNRS UMR 8104, Université de Paris, Paris, France; NACRe Network-Nutrition and Cancer Research Network, Jouy-en-Josas, France.
Lancet Gastroenterol Hepatol. 2022 Dec;7(12):1128-1140. doi: 10.1016/S2468-1253(22)00169-8. Epub 2022 Aug 8.
Epidemiological studies have suggested a role for ultra-processed foods in numerous chronic inflammatory diseases such as inflammatory bowel diseases and metabolic syndrome. Preclinical and clinical studies are accumulating to better decipher the effects of various aspects of food processing and formulation on the aetiology of chronic, debilitating inflammatory diseases. In this Review, we provide an overview of the current data that highlight an association between ultra-processed food consumption and various chronic diseases, with a focus on epidemiological evidence and mechanistic insights involving the intestinal microbiota.
流行病学研究表明，超加工食品在许多慢性炎症性疾病中起作用，如炎症性肠病和代谢综合征。越来越多的临床前和临床研究正在深入研究，以更好地阐明食品加工和配方的各个方面对慢性、使人衰弱的炎症性疾病病因的影响。在这篇综述中，我们概述了当前的数据，这些数据强调了超加工食品消费与各种慢性疾病之间的关联，重点是涉及肠道微生物群的流行病学证据和机制见解。
