Lacasse Jesse M, Gomez-Perales Eamonn, Brake Wayne G
Centre for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal H4B 1R6, Canada.
Centre for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal H4B 1R6, Canada.
Front Neuroendocrinol. 2022 Oct;67:101020. doi: 10.1016/j.yfrne.2022.101020. Epub 2022 Aug 8.
Research on hormonal contraceptives (HC) in animal models is lacking, and as a result, so is our understanding of the impact of HC on the brain and behavior. Here, we provide a review of the pharmacology of HC, as well as the methodology and best practices for designing a model of HC in female rats. We outline specific methodological considerations regarding dosing, route of administration, exposure time/timing, and selecting a control group. We also provide a framework outlining important levels of analysis for thinking about the impact of HC on behavioral and neurobiological outcomes. The purpose of this review is to equip researchers with foundational knowledge, and some basic elements of experimental design for future studies investigating the impact of HC on the brain and behavior of female rats.
关于激素避孕药（HC）在动物模型中的研究尚缺，因此，我们对HC对大脑和行为影响的了解也很匮乏。在此，我们综述了HC的药理学，以及在雌性大鼠中设计HC模型的方法和最佳实践。我们概述了给药剂量、给药途径、暴露时间/时机以及选择对照组等具体方法学考量。我们还提供了一个框架，概述了思考HC对行为和神经生物学结果影响的重要分析层面。本综述的目的是为研究人员提供基础知识，以及一些实验设计的基本要素，以便未来开展研究调查HC对雌性大鼠大脑和行为的影响。
