Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba.
Ibaraki Western Medical Center.
J Atheroscler Thromb. 2021 Dec 1;28(12):1298-1306. doi: 10.5551/jat.61390. Epub 2021 Feb 18.
Seaweed contains soluble dietary fibers, potassium, and flavonoids and was recently reported to be inversely associated with the risk of coronary heart disease and mortality from stroke. However, epidemiological evidence on this issue has remained scarce.
At the baseline survey of four Japanese communities between 1984 and 2000, we enrolled 6,169 men and women aged 40-79 years who had no history of cardiovascular disease. We assessed their seaweed intake using the data from a 24 h dietary recall survey and categorized the intake into four groups (0, 1-5.5, 5.5-15, and ≥ 15 g/day). We used sex-specific Cox proportional hazards models to examine the association between seaweed intake and risk of cardiovascular disease (stroke, stroke subtypes, and coronary heart disease).
During the 130,248 person-year follow-up, 523 cases of cardiovascular disease occurred: 369 cases of stroke and 154 cases of coronary heart disease. Seaweed intake levels were inversely associated with the risk of total stroke and cerebral infarction among men but not among women. Adjustment for cardiovascular risk factors did not change the associations: the hazard ratios (95% confidence intervals; P for trend) for the highest versus lowest categories of seaweed intake were 0.63 (0.42-0.94; 0.01) for total stroke and 0.59 (0.36-0.97; 0.03) for cerebral infarction. No associations were observed between seaweed intake and risks of intraparenchymal hemorrhage, subarachnoid hemorrhage, or coronary heart disease among men or women.
We found an inverse association between seaweed intake and risk of total stroke, especially that from cerebral infarction, among Japanese men.
海藻含有可溶性膳食纤维、钾和类黄酮，最近有报道称其与冠心病和中风死亡率的风险呈负相关。然而，关于这个问题的流行病学证据仍然很少。
在 1984 年至 2000 年间四个日本社区的基线调查中，我们招募了 6169 名年龄在 40-79 岁、无心血管疾病病史的男性和女性。我们使用 24 小时膳食回忆调查的数据评估他们的海藻摄入量，并将摄入量分为四组（0、1-5.5、5.5-15 和≥15 g/天）。我们使用性别特异性 Cox 比例风险模型来检查海藻摄入量与心血管疾病（中风、中风亚型和冠心病）风险之间的关联。
在 130248 人年的随访期间，发生了 523 例心血管疾病：369 例中风和 154 例冠心病。海藻摄入量与男性总中风和脑梗死的风险呈负相关，但与女性无关。调整心血管危险因素后，这些关联并未改变：最高与最低海藻摄入量组之间的风险比（95%置信区间；趋势 P 值）分别为总中风的 0.63（0.42-0.94；0.01）和脑梗死的 0.59（0.36-0.97；0.03）。在男性或女性中，均未观察到海藻摄入量与脑实质出血、蛛网膜下腔出血或冠心病风险之间存在关联。
我们发现日本男性海藻摄入量与总中风风险呈负相关，尤其是脑梗死风险。
