Welgan P, Meshkinpour H, Hoehler F
Psychosom Med. 1985 Mar-Apr;47(2):139-49. doi: 10.1097/00006842-198503000-00005.
The present investigation was designed to study the role of stress on the physiologic mechanisms of the colon in irritable bowel syndrome (IBS). Patients with IBS were compared with normal controls during resting and stress (mental arithmetic, cold pressor, and fear stressor). The results indicated that IBS patients had significantly higher motor activity than normals in the resting state but did not differ from them in the mean dominant frequency of the basal electrical rhythm (BER) or the proportion of the time they had 2-4 cycles per minute (cpm) slow-wave activity. Stress significantly increased motor activity in both groups although they did not differ significantly from each other during stress. Stress increased the proportion of 2-4 cpm slow-wave activity in IBS patients, but decreased in the controls. The type of stressor, however, did not influence either motor or electrical activity. Although IBS patients were significantly older than the controls and scored higher on the MMPI scales of Hypochondriasis, Hysteria, and Depression, these factors did not significantly influence differences in motor or electrical activity between the groups. The results are discussed in terms of the role of learning in the colon.
本研究旨在探讨应激在肠易激综合征（IBS）结肠生理机制中的作用。在静息状态和应激状态（心算、冷加压和恐惧应激）下，将IBS患者与正常对照组进行比较。结果表明，IBS患者在静息状态下的运动活性显著高于正常人，但在基础电节律（BER）的平均主导频率或每分钟有2 - 4次慢波活动的时间比例方面与正常人无差异。应激显著增加了两组的运动活性，尽管在应激期间两组之间无显著差异。应激增加了IBS患者2 - 4次/分钟慢波活动的比例，但在对照组中则降低。然而，应激源的类型对运动或电活动均无影响。尽管IBS患者比对照组年龄显著更大，且在明尼苏达多相人格调查表（MMPI）的疑病、癔症和抑郁量表上得分更高，但这些因素并未显著影响两组之间运动或电活动的差异。将根据学习在结肠中的作用对结果进行讨论。
