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用于药物递送应用的生物活性材料的3D打印

3D printing of bioactive materials for drug delivery applications.

作者信息

Nasiri Golara, Ahmadi Sepideh, Shahbazi Mohammad-Ali, Nosrati-Siahmazgi Vahideh, Fatahi Yousef, Dinarvand Rassoul, Rabiee Mohammad, Haftlang Farahnaz, Kim Hyoung Seop, Rabiee Navid

机构信息

Department of Tissue Engineering and Cell Therapy, School of Advanced Technologies in Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Expert Opin Drug Deliv. 2022 Sep;19(9):1061-1080. doi: 10.1080/17425247.2022.2112944. Epub 2022 Aug 22.

Abstract

INTRODUCTION

Three-dimensional (3D) printing, also known as additive manufacturing (AM), is a modern technique/technology, which makes it possible to construct 3D objects from computer-aided design (CAD) digital models. This technology can be used in the progress of drug delivery systems, where porosity has played important role in attaining an acceptable level of biocompatibility and biodegradability with improved therapeutic effects. 3D printing may also provide the user possibility to control the dosage of each ingredient in order to a specific purpose, and makes it probable to improve the formulation of drug delivery systems.

AREAS COVERED

This article covers the 3D printing technologies, bioactive materials including natural and synthetic polymers as well as some ceramics and minerals and their roles in drug delivery systems.

EXPERT OPINION

This technology is feasible to fabricate drug products by incorporating multiple drugs in different parts in such a mode that these drugs can release from the section at a predetermined rate. Furthermore, this 3D printing technology has the potential to transform personalized therapy to various age-groups by design flexibility and precise dosing. In recent years, the potential use of this technology can be realized in a clinical situation where patients will acquire individualized medicine as per their requirement.

摘要

引言

三维(3D)打印,也称为增材制造(AM),是一种现代技术,它能够根据计算机辅助设计(CAD)数字模型构建三维物体。该技术可应用于药物递送系统的研发过程,其中孔隙率对于实现可接受的生物相容性和生物降解性水平以及提高治疗效果起着重要作用。3D打印还可为用户提供根据特定目的控制每种成分剂量的可能性,并有可能改进药物递送系统的配方。

涵盖领域

本文涵盖了3D打印技术、生物活性材料,包括天然和合成聚合物以及一些陶瓷和矿物质,以及它们在药物递送系统中的作用。

专家观点

通过以这些药物能够以预定速率从该部分释放的方式在不同部分中掺入多种药物来制造药品,这项技术是可行的。此外,这种3D打印技术具有通过设计灵活性和精确给药将个性化治疗转变为适用于各个年龄组的潜力。近年来,这项技术的潜在用途可在临床环境中得以实现,在这种环境下患者将能够根据自身需求获得个性化药物。

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