Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Cells. 2022 Aug 4;11(15):2420. doi: 10.3390/cells11152420.
Obesity is associated with increased cardiovascular morbidity. Adult patients with growth hormone deficiency (GHD) show morpho-functional cardiological alterations. A total of 353 overweight/obese patients are enrolled in the period between 2009 and 2019 to assess the relationships between GH secretory capacity and the metabolic phenotype, cardiovascular risk factors, body composition and cardiac echocardiographic parameters. All patients underwent GHRH + arginine test to evaluate GH secretory capacity, DEXA for body composition assessment and transthoracic echocardiography. Blood samples are also collected for the evaluation of metabolic parameters. In total, 144 patients had GH deficiency and 209 patients had normal GH secretion. In comparing the two groups, we found significant differences in body fat distribution with predominantly visceral adipose tissue accumulation in GHD patients. Metabolic syndrome is more prevalent in the GHD group. In particular, fasting glycemia, triglycerides and systolic and diastolic blood pressure are found to be linearly correlated with GH secretory capacity. Epicardial fat thickness, E/A ratio and indexed ventricular mass are worse in the GHD group. In the population studied, metabolic phenotype, body composition, cardiovascular risk factors and cardiac morphology are found to be related to the GH secretory capacity. GH secretion in the obese patient seems to be an important determinant of metabolic health.
肥胖与心血管发病率增加有关。生长激素缺乏症（GHD）的成年患者表现出形态功能学心脏改变。2009 年至 2019 年期间共纳入 353 名超重/肥胖患者，以评估 GH 分泌能力与代谢表型、心血管危险因素、身体成分和心脏超声心动图参数之间的关系。所有患者均接受 GHRH +精氨酸试验以评估 GH 分泌能力、DEXA 进行身体成分评估和经胸超声心动图检查。还采集血样以评估代谢参数。共有 144 名患者存在 GH 缺乏，209 名患者 GH 分泌正常。在比较两组时，我们发现 GH 缺乏组的身体脂肪分布存在显著差异，主要表现为内脏脂肪组织堆积。代谢综合征在 GHD 组更为普遍。具体而言，空腹血糖、甘油三酯以及收缩压和舒张压与 GH 分泌能力呈线性相关。E/A 比值和心室质量指数在 GHD 组更差。在研究人群中，代谢表型、身体成分、心血管危险因素和心脏形态与 GH 分泌能力有关。肥胖患者的 GH 分泌似乎是代谢健康的重要决定因素。
