Zhang Renjie, Zhang Yu, Liu Zheran, Pei Yiyan, Xu Ping, Chong Weelic, Hai Yang, He Ling, He Yan, Yu Jiayi, Wang Jingjing, Fang Fang, Peng Xingchen
Department of Biotherapy, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Evidence-Based Medicine Center, Affiliated Hospital of Chengdu University, Chengdu 610084, China.
Cancers (Basel). 2022 Jul 30;14(15):3717. doi: 10.3390/cancers14153717.
Vitamin D deficiency is related to increased cancer risk and deaths. However, whether vitamin D supplementation reduces cancer mortality remains unclear, and several randomized controlled trials yield inconsistent results.
Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched from their inception until 28 June 2022, for randomized controlled trials investigating vitamin D supplementation. Pooled relative risks (RRs) and their 95% confidence intervals (CIs) were estimated. Trials with vitamin D supplementation combined with calcium supplementation versus placebo alone and recruiting participants with cancer at baseline were excluded in the present study.
This study included 12 trials with a total of 72,669 participants. Vitamin D supplementation did not reduce overall cancer mortality (RR 0.96, 95% CI 0.80-1.16). However, vitamin D supplementation was associated with a reduction in lung cancer mortality (RR 0.63, 95% CI 0.45-0.90).
Vitamin D supplementation could not reduce cancer mortality in this highly purified meta-analysis. Further RCTs that evaluate the association between vitamin D supplementation and total cancer mortality are still needed.
维生素D缺乏与癌症风险增加和死亡有关。然而，补充维生素D是否能降低癌症死亡率仍不明确，多项随机对照试验结果不一致。
检索Medline、Embase和Cochrane对照试验中心注册库自建库至2022年6月28日期间有关补充维生素D的随机对照试验。估计合并相对风险（RR）及其95%置信区间（CI）。本研究排除了补充维生素D联合补钙与单纯安慰剂对照且基线时招募癌症患者的试验。
本研究纳入12项试验，共72669名参与者。补充维生素D并未降低总体癌症死亡率（RR 0.96，95%CI 0.80-1.16）。然而，补充维生素D与肺癌死亡率降低相关（RR 0.63，95%CI 0.45-0.90）。
在这项高度纯化的荟萃分析中，补充维生素D不能降低癌症死亡率。仍需要进一步的随机对照试验来评估补充维生素D与总体癌症死亡率之间的关联。
