Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Environment Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Int J Environ Res Public Health. 2022 Aug 3;19(15):9551. doi: 10.3390/ijerph19159551.
Liver cancer is the most common cancer in Northern Thailand, mainly due to the dietary preference for raw fish, which can lead to infection by the parasite, , a causal agent of cholangiocarcinoma. We conducted a temporal trend analysis of cross-sectional incidence rates of liver cancer in Lampang, Northern Thailand. Liver cancer data from 1993-2012 were extracted from Lampang Cancer Registry. The multiple imputation by chained equations method was used to impute missing histology data. Imputed data were analyzed using Joinpoint and age-period-cohort (APC) models to characterize the incidence rates by gender, region, and histology, considering hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). We observed a significant annual increase in CCA incidence and a considerable decrease in HCC incidence for both genders in Lampang. The APC analysis suggested that CCA incidence rates were higher in older ages, younger cohorts, and later years of diagnosis. In contrast, HCC incidence rates were higher in older generations and earlier years of diagnosis. Further studies of potential risk factors of CCA are needed to better understand and address the increasing burden of CCA in Lampang. Our findings may help to draw public attention to cholangiocarcinoma prevention and control in Northern Thailand.
在泰国北部，肝癌是最常见的癌症，主要是由于人们喜欢食用生鱼片，这可能导致寄生虫感染，进而引发胆管癌。我们对泰国北部廊开府肝癌的发病率进行了时间趋势分析。从廊开癌症登记处提取了 1993 年至 2012 年的肝癌数据。采用链式方程的多重插补法对缺失的组织学数据进行了插补。使用 Joinpoint 和年龄-时期-队列 (APC) 模型对男女、地区和组织学的发病率进行了分析，同时考虑了肝细胞癌 (HCC) 和胆管癌 (CCA)。我们观察到，在廊开，男女肝癌的发病率均呈显著的年度上升趋势，而胆管癌的发病率则显著下降。APC 分析表明，在较年长、较年轻的队列和较晚的诊断年份，胆管癌的发病率较高。相比之下，肝癌的发病率在较老的世代和较早的诊断年份更高。进一步研究胆管癌的潜在危险因素有助于更好地了解和应对廊开胆管癌负担的增加。我们的研究结果可能有助于引起公众对泰国北部胆管癌预防和控制的关注。
