Department of Rehabilitation and Physical Medicine, Medical University, 90-700 Łódź, Poland.
Neuroorthopedics and Neurology Clinic and Polyclinic, National Institute of Geriatrics, Rheumatology and Rehabilitation, 02-637 Warsaw, Poland.
Int J Environ Res Public Health. 2022 Aug 8;19(15):9743. doi: 10.3390/ijerph19159743.
(1) Background: The influence of serotonin on many regulatory mechanisms has not been sufficiently studied. The use of a physical method, assuming the possibility of its action on increasing the concentration of serotonin, may be the direction of therapy limiting the number of antidepressants used. The aim of the research was to study the effects of low-frequency magnetic fields of different characteristics on the circadian profile of serotonin in men with low back pain. (2) Methods: 16 men with back pain syndrome participated in the study. The patients were divided into two groups. In group 1, magnetotherapy (2.9 mT, 40 Hz, square wave, bipolar) was applied at 10.00 a.m. In group 2, the M2P2 magnetic stimulation program of the Viofor JPS device was used. Treatments in each group lasted 3 weeks, 5 days each, with breaks for Saturday and Sunday. The daily serotonin profile was determined the day before the exposure and the day after the last treatment. Blood samples (at night with red light) were collected at 8:00, 12:00, 16:00, 24:00, and 4:00. The patients did not suffer from any chronic or acute disease and were not taking any medications. (3) Results: In group 1, a significant increase in serotonin concentration was observed after 15 treatments at 4:00. In group 2, a significant increase in serotonin concentration was observed at 8:00 after the end of the treatments. In comparison between magnetotherapy and magnetic stimulation, the time points at which differences appeared after the application of serotonin occurred due to the increase in its concentrations after the application of magnetic stimulation. (4) Conclusions: Magnetotherapy and magnetic stimulation, acting in a similar way, increase the concentration of serotonin. Weak magnetic fields work similarly to the stronger ones used in TMS. It is possible to use them in the treatment of mental disorders or other diseases with low serotonin concentrations.
(1) 背景：血清素对许多调节机制的影响尚未得到充分研究。使用物理方法，假设其作用有可能增加血清素的浓度，可能是限制使用抗抑郁药数量的治疗方向。本研究的目的是研究不同特性的低频磁场对男性腰痛患者血清素昼夜节律谱的影响。
(2) 方法：16 名腰痛综合征患者参与了这项研究。患者被分为两组。在第 1 组中，在上午 10 点进行磁疗（2.9 mT、40 Hz、方波、双极）。在第 2 组中，使用了 Viofor JPS 设备的 M2P2 磁刺激程序。每组治疗持续 3 周，每周 5 天，周六和周日休息。在暴露前一天和最后一次治疗后一天确定每日血清素谱。在晚上用红光采集 8:00、12:00、16:00、24:00 和 4:00 的血液样本。患者没有患任何慢性或急性疾病，也没有服用任何药物。
(3) 结果：在第 1 组中，在 15 次治疗后 4:00 观察到血清素浓度显著增加。在第 2 组中，治疗结束后 8:00 观察到血清素浓度显著增加。与磁疗和磁刺激相比，在应用磁刺激后，由于其浓度增加，出现差异的时间点是由于应用后血清素浓度增加所致。
(4) 结论：磁疗和磁刺激以类似的方式增加血清素浓度。弱磁场的作用类似于 TMS 中使用的更强磁场。可以将它们用于治疗精神障碍或其他血清素浓度低的疾病。
