Department of Clinical and Experimental Medicine, Internal Medicine, Garibaldi-Nesima Hospital, University of Catania, 95122 Catania, Italy.
Faculty of Medicine and Surgery, "Kore" University of Enna, 94100 Enna, Italy.
Int J Mol Sci. 2022 Jul 28;23(15):8320. doi: 10.3390/ijms23158320.
Metformin, a molecule belonging to the biguanide family, represents one of the most commonly prescribed medications for the treatment of diabetes mellitus in the world. Over the sixty years during which it has been used, many benefits have been described, which are not limited to the treatment of diabetes mellitus. However, since metformin is similar to other members of the same drug family, there is still much concern regarding the risk of lactic acidosis. This article aims to highlight the correlation between the use of metformin and the onset of renal damage or lactic acidosis. Metformin-associated lactic acidosis exists; however, it is rare. The appropriate use of the drug, under safe conditions, induces benefits without risks.
二甲双胍，属于双胍类家族的一种分子，是世界上治疗糖尿病最常用的药物之一。在六十多年的使用过程中，已经描述了许多益处，不仅限于治疗糖尿病。然而，由于二甲双胍与同一家族的其他药物相似，因此仍然存在很多关于乳酸酸中毒风险的担忧。本文旨在强调二甲双胍的使用与肾损伤或乳酸酸中毒的发生之间的相关性。二甲双胍相关性乳酸酸中毒确实存在，但很少见。在安全条件下，正确使用该药物会带来益处而没有风险。
