干扰素与抗病毒蛋白信使核糖核酸的比较分析
Comparative analysis of interferon and antiviral protein messenger RNAs.
作者信息
Ershov F I, Sokolova T M, Tazulakhova E B, Kadyrova A A, Kisling U, Novokhatsky A S
出版信息
Acta Virol. 1979 Jan;23(1):32-9.
A comparative analysis of interferon and antiviral protein messenger RNAs was carried out. Differences in their biological activities and sedimentation coefficients were found. In RNA preparations from superinduced cells (cells treated with poly(I).poly(C) and antimetabolites) and from cells treated with interferon, messenger RNAs possesing interferon and antiviral activities were detected. The results suggest the existence of two types of mRNA (for interferon and antiviral protein, respectively) and support the hypothetic model of interferon action via an antiviral protein.
对干扰素和抗病毒蛋白质信使核糖核酸进行了比较分析。发现了它们在生物活性和沉降系数方面的差异。在来自超诱导细胞（用聚肌苷酸-聚胞苷酸和抗代谢物处理的细胞）以及用干扰素处理的细胞的核糖核酸制剂中，检测到了具有干扰素和抗病毒活性的信使核糖核酸。结果表明存在两种类型的信使核糖核酸（分别对应干扰素和抗病毒蛋白质），并支持了通过抗病毒蛋白质发挥作用的干扰素作用假说模型。
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