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[抗病毒蛋白作用的非特异性]

[Nonspecificity of antiviral protein action].

作者信息

Sokolova T M, Kisling U, Ershov F I

出版信息

Biull Eksp Biol Med. 1978 Jun;85(6):720-1.

PMID:96890
Abstract

The authors studied the antiviral activity of the informative RNA of antiviral protein (M-RNA AVP) isolated from the cells following superinduction of interferon in them for the purpose of ascertaining the action specificity of the product of their translation--AVP. Following the administration of M-RAN AVP a marked (from 1 to 5 lg PFU/mil) reduction of the infectious titres was observed in the homologous and heterologous cells. RNA preparations from control (noninduced) cells possessed a weak (0.4--0.1 lg PFU/mil) antiviral activity.

摘要

作者研究了从经干扰素超诱导的细胞中分离出的抗病毒蛋白信息RNA(M-RNA AVP)的抗病毒活性,以确定其翻译产物——AVP的作用特异性。给予M-RAN AVP后,在同源和异源细胞中均观察到感染滴度显著降低(从1至5 lg PFU/毫升)。来自对照(未诱导)细胞的RNA制剂具有较弱的(0.4 - 0.1 lg PFU/毫升)抗病毒活性。

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