Park Hae Min, Lee Won June, Lim Han Woong, Kim Yu Jeong
Department of Ophthalmology, Hanyang University Hospital, Hanyang University College of Medicine, 222-1, Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea.
J Clin Med. 2022 Aug 5;11(15):4577. doi: 10.3390/jcm11154577.
Meibomian gland dysfunction (MGD), a chronic abnormality of meibomian glands, causes various dry eye symptoms. Principal treatments for MGD are warm compression and mechanical squeezing of the eyelids. In this study, the immediate impact of this treatment on tear film lipid layer thickness (TFLLT) and the meibomian gland (MG) structure in MGD and normal groups was investigated to establish its efficacy and potential side effects. Nineteen MGD patients and seven normal subjects were enrolled. TFLLT and blinking parameters were evaluated before and after warm compression. Morphological changes of MG structures after mechanical squeezing were analyzed using Image J and Fiji. Differential analysis of the MGD and the normal groups of TFLLT changes after warm compression showed a significant increase in the normal group. In normal eyes, the average, maximum, and minimum TFLLT were significantly increased, and in the MGD group, only the minimum TFLLT was improved. Blinking parameters showed no significant change in either group. Morphometric analysis showed no damages of the MG after MG squeezing. A significant increase in MG length was observed in normal eyes. Warm compression immediately increased TFLLT more significantly in the normal group than in the MGD patients. Mechanical expression is a safe therapeutic option without remarkable structural MG damages.
睑板腺功能障碍（MGD）是睑板腺的一种慢性异常，会导致各种干眼症状。MGD的主要治疗方法是眼睑热敷和机械挤压。在本研究中，研究了该治疗方法对MGD组和正常组泪膜脂质层厚度（TFLLT）和睑板腺（MG）结构的即时影响，以确定其疗效和潜在副作用。纳入了19例MGD患者和7名正常受试者。在热敷前后评估TFLLT和眨眼参数。使用Image J和Fiji分析机械挤压后MG结构的形态学变化。对热敷后MGD组和正常组TFLLT变化的差异分析显示，正常组有显著增加。在正常眼中，平均、最大和最小TFLLT均显著增加，而在MGD组中，仅最小TFLLT有所改善。眨眼参数在两组中均无显著变化。形态计量分析显示MG挤压后MG无损伤。在正常眼中观察到MG长度显著增加。热敷使正常组的TFLLT立即增加的幅度比MGD患者组更显著。机械挤压是一种安全的治疗选择，不会对MG结构造成明显损伤。
