Department of Pathology, Chemical Pathology Division, National Health Laboratory Service (NHLS) and Stellenbosch University, Tygerberg Hospital, Cape Town 7505, South Africa.
SAMRC/CPUT/Cardiometabolic Health Research Unit, Department of Biomedical Science, Faculty of Health & Wellness Sciences, Cape Peninsula University of Technology, Cape Town 7530, South Africa.
Nutrients. 2022 Jul 30;14(15):3147. doi: 10.3390/nu14153147.
Vitamin D reportedly plays an important role in the pathogenesis of diabetes mellitus; however, this role is unclear and debated. This study investigated the association between 25(OH) vitamin D, vitamin D-binding proteins, and vitamin D receptor (VDR) polymorphisms in healthy individuals and those with prediabetes and type 2 diabetes mellitus (T2D) from South Africa. A cross-sectional study was conducted involving subjects of mixed ancestry aged ≥20 years. Males presented with higher mean 25(OH) vitamin D levels than females, while females exhibited significantly higher serum vitamin D-binding protein levels. Significant differences in mean 25(OH) vitamin D levels were observed in normo-glycaemic, prediabetes, screen-detected DM, and known DM individuals. Vitamin D receptor SNPs and were not associated with glycaemic status. was not associated with 25(OH) vitamin D deficiency, while was associated with vitamin D insufficiency. This study showed a high prevalence of vitamin D deficiency/insufficiency in this South African population, with decreased vitamin D levels observed in hyperglycaemic individuals, which was not linked to either vitamin D-binding protein or polymorphisms in of the gene. These results may be used as a platform for further research into diagnosis and treatment of hyperglycaemia.
维生素 D 据称在糖尿病的发病机制中发挥着重要作用；然而，其作用尚不清楚，且存在争议。本研究调查了南非健康个体、前驱糖尿病和 2 型糖尿病（T2DM）个体中 25（OH）维生素 D、维生素 D 结合蛋白和维生素 D 受体（VDR）多态性之间的关联。进行了一项横断面研究，纳入了年龄≥20 岁的混合血统受试者。男性的平均 25（OH）维生素 D 水平高于女性，而女性的血清维生素 D 结合蛋白水平显著更高。在血糖正常、前驱糖尿病、筛查发现的糖尿病和已知的糖尿病个体中，观察到平均 25（OH）维生素 D 水平存在显著差异。维生素 D 受体 SNPs 和 与血糖状态无关。 与 25（OH）维生素 D 缺乏无关，而 与维生素 D 不足有关。本研究表明，该南非人群中维生素 D 缺乏/不足的患病率很高，且在高血糖个体中观察到维生素 D 水平降低，但与维生素 D 结合蛋白或 基因的 多态性无关。这些结果可用作进一步研究高血糖症的诊断和治疗的基础。
