Department of Chemistry, Mississippi State University, Starkville, USA.
Department of Internal Medicine, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, India.
Oxid Med Cell Longev. 2022 Jul 31;2022:7934442. doi: 10.1155/2022/7934442. eCollection 2022.
Neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD) are becoming more frequent as the age increases. Contemporary therapies provide symptom resolution instead of targeting underlying pathological pathways. Consequently, there is considerable heterogeneity in response to treatment. Research has elucidated multiple potential of pathophysiological mechanisms contributing to neurodegenerative conditions, among which oxidative stress pathways appear to be suitable drug targets. The oxidative stress pathway has given rise to numerous novel pharmacological therapies that may provide a new avenue for neurodegenerative diseases. For example, SKQ (plastoquinone), MitoVitE, vitamin E, SOD mimic, MitoTEMPO (SOD mimetic), and bioactive molecules like curcumin and vitamin C have indeed been examined. To better understand how oxidative stress contributes to neurodegenerative diseases (such as Alzheimer's and Parkinson's), we analyzed the medicinal qualities of medicines that target markers in the cellular oxidative pathways. The specific pathway by which mitochondrial dysfunction causes neurodegeneration will require more investigation. An animal study should be carried out on medications that tackle cellular redox mechanisms but are not currently licensed for use in the management of neurodegenerative conditions.
神经退行性疾病，如阿尔茨海默病（AD）和帕金森病（PD），随着年龄的增长变得越来越常见。当代的治疗方法提供的是症状缓解，而不是针对潜在的病理途径。因此，治疗反应存在相当大的异质性。研究已经阐明了导致神经退行性疾病的多种潜在病理生理机制，其中氧化应激途径似乎是合适的药物靶点。氧化应激途径已经产生了许多新的药理学治疗方法，可能为神经退行性疾病提供了新的途径。例如，SKQ（质体醌）、MitoVitE、维生素 E、SOD 模拟物、MitoTEMPO（SOD 模拟物）以及姜黄素和维生素 C 等生物活性分子已被研究。为了更好地理解氧化应激如何导致神经退行性疾病（如阿尔茨海默病和帕金森病），我们分析了针对细胞氧化途径中标记物的药物的药用特性。线粒体功能障碍导致神经变性的具体途径需要进一步研究。应该对针对细胞氧化还原机制的药物进行动物研究，但这些药物目前尚未获得用于治疗神经退行性疾病的许可。
