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纳米结构与钙离子对改善钛植入物生物活性的协同效应。

Synergistic effect of nanostructure and calcium ions on improving the bioactivity of titanium implants.

作者信息

Zhang Yue, Wang Jingwen, Hosseinijenab Shahrzad, Yu Yiqiang, Lv Chao, Luo Cheng, Zhang Weijie, Sun Xi, Zhang Lei

机构信息

Department of Prosthodontics, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, People's Republic of China.

Department of Endodontics, School and Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, People's Republic of China.

出版信息

R Soc Open Sci. 2022 Aug 10;9(8):220206. doi: 10.1098/rsos.220206. eCollection 2022 Aug.

DOI:10.1098/rsos.220206
PMID:35958094
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9364004/
Abstract

Surface structure and composition play essential roles in the osseointegration of titanium implants. In the present study, a nanoscale surface structure incorporated with calcium ions was fabricated on a titanium surface by hydrothermal treatment. The characteristics of the surfaces were analysed, and the bioactivity of the samples was evaluated and . nm-Ti and nm/Ca-Ti surfaces were significantly more hydrophilic than control-Ti surfaces. nm/Ca-Ti samples showed much faster bone-like apatite precipitation in simulated body fluid than the other samples. The results of MC3T3-E1 cell tests demonstrated that both nm-Ti and nm/Ca-Ti surfaces accelerated cell adhesion and proliferation. The highest level of osteogenesis-related genes (Runx2, bone morphogenetic protein-2, osteopontin and osteocalcin) were observed in nm/Ca-Ti samples, followed by nm-Ti samples. Alizarin red staining experiment showed that the amount of extracellular matrix mineralized nodules in nm/Ca-Ti group was significantly higher than others. In animal experiments using SD rats, nm/Ca-Ti showed the highest value of new bone formation at two and four weeks. The present study suggested that the nanostructure and calcium ions showed synergetic effects on accelerating bone-like apatite precipitation and osteoblast cell growth and differentiation. Animal experiment further indicated that such surface could promote early osteogenesis.

摘要

表面结构和组成在钛植入物的骨整合中起着至关重要的作用。在本研究中，通过水热处理在钛表面制备了一种结合钙离子的纳米级表面结构。分析了表面特性，并评估了样品的生物活性。纳米钛（nm-Ti）和纳米钙钛（nm/Ca-Ti）表面比对照钛（control-Ti）表面明显更具亲水性。nm/Ca-Ti样品在模拟体液中显示出比其他样品更快的类骨磷灰石沉淀。MC3T3-E1细胞测试结果表明，nm-Ti和nm/Ca-Ti表面均加速了细胞粘附和增殖。在nm/Ca-Ti样品中观察到最高水平的成骨相关基因（Runx2、骨形态发生蛋白-2、骨桥蛋白和骨钙素），其次是nm-Ti样品。茜素红染色实验表明，nm/Ca-Ti组细胞外基质矿化结节的数量明显高于其他组。在使用SD大鼠的动物实验中，nm/Ca-Ti在两周和四周时显示出新骨形成的最高值。本研究表明，纳米结构和钙离子在加速类骨磷灰石沉淀以及成骨细胞生长和分化方面具有协同作用。动物实验进一步表明，这种表面可以促进早期成骨。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ffd/9364004/42d23a1c3e4f/rsos220206f08.jpg
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本文引用的文献

1
A nanoporous titanium surface promotes the maturation of focal adhesions and formation of filopodia with distinctive nanoscale protrusions by osteogenic cells.纳米多孔钛表面可促进成骨细胞成熟黏着斑的形成以及丝状伪足的形成，这些丝状伪足具有独特的纳米级突起。
Acta Biomater. 2017 Sep 15;60:339-349. doi: 10.1016/j.actbio.2017.07.022. Epub 2017 Jul 17.
2
Nanotubular topography enhances the bioactivity of titanium implants.纳米管状形貌增强了钛植入物的生物活性。
Nanomedicine. 2017 Aug;13(6):1913-1923. doi: 10.1016/j.nano.2017.03.017. Epub 2017 Apr 8.
3
Enhanced osteogenic activity of poly ether ether ketone using calcium plasma immersion ion implantation.
采用钙等离子体浸没离子注入增强聚醚醚酮的成骨活性。
Colloids Surf B Biointerfaces. 2016 Jun 1;142:192-198. doi: 10.1016/j.colsurfb.2016.02.056. Epub 2016 Feb 27.
4
Nano-thick calcium oxide armed titanium: boosts bone cells against methicillin-resistant Staphylococcus aureus.纳米厚氧化钙武装的钛：增强骨细胞对抗耐甲氧西林金黄色葡萄球菌的能力。
Sci Rep. 2016 Feb 22;6:21761. doi: 10.1038/srep21761.
5
Potential mechanisms underlying the Runx2 induced osteogenesis of bone marrow mesenchymal stem cells.Runx2诱导骨髓间充质干细胞成骨的潜在机制。
Am J Transl Res. 2015 Dec 15;7(12):2527-35. eCollection 2015.
6
Partial oxidation of TiN coating by hydrothermal treatment and ozone treatment to improve its osteoconductivity.通过水热处理和臭氧处理对TiN涂层进行部分氧化以提高其骨传导性。
Mater Sci Eng C Mater Biol Appl. 2016 Feb;59:542-548. doi: 10.1016/j.msec.2015.10.024. Epub 2015 Oct 13.
7
Hydrothermal treatment of titanium alloys for the enhancement of osteoconductivity.水热处理钛合金以提高其骨传导性。
Mater Sci Eng C Mater Biol Appl. 2015 Apr;49:430-435. doi: 10.1016/j.msec.2015.01.031. Epub 2015 Jan 8.
8
Enhanced osseointegration of titanium implants with nanostructured surfaces: an experimental study in rabbits.具有纳米结构表面的钛植入物的增强骨整合：兔的实验研究。
Acta Biomater. 2015 Jan;11:494-502. doi: 10.1016/j.actbio.2014.10.017. Epub 2014 Oct 23.
9
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Mater Sci Eng C Mater Biol Appl. 2013 Jan 1;33(1):251-8. doi: 10.1016/j.msec.2012.08.037. Epub 2012 Sep 6.
10
Role and regulation of RUNX2 in osteogenesis.RUNX2在骨生成中的作用与调控。
Eur Cell Mater. 2014 Oct 23;28:269-86. doi: 10.22203/ecm.v028a19.