Department of Prosthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Nanomedicine. 2017 Aug;13(6):1913-1923. doi: 10.1016/j.nano.2017.03.017. Epub 2017 Apr 8.
Surface modification on titanium implants plays an important role in promoting mesenchymal stem cell (MSC) response to enhance osseointegration persistently. In this study, nano-scale TiO nanotube topography (TNT), micro-scale sand blasted-acid etched topography (SLA), and hybrid sand blasted-acid etched/nanotube topography (SLA/TNT) were fabricated on the surfaces of titanium implants. Although the initial cell adherence at 60 min among TNT, SLA and TNT/SLA was not different, SLA and SLA/TNT presented to be rougher and suppressed the proliferation of MSC. TNT showed hydrophilic surface and balanced promotion of cellular functions. After being implanted in rabbit femur models, TNT displayed the best osteogenesis inducing ability as well as strong bonding strength to the substrate. These results indicate that nano-scale TNT provides favorable surface topography for improving the clinical performance of endosseous implants compared with micro and hybrid micro/nano surfaces, suggesting a promising and reliable surface modification strategy of titanium implants for clinical application.
钛植入物表面改性在促进间充质干细胞（MSC）反应以增强骨整合方面起着重要作用。在本研究中，在钛植入物表面制备了纳米级 TiO2 纳米管形貌（TNT）、微尺度喷砂酸蚀形貌（SLA）和混合喷砂酸蚀/纳米管形貌（SLA/TNT）。尽管在 60 分钟时 TNT、SLA 和 TNT/SLA 之间的初始细胞黏附没有差异，但 SLA 和 SLA/TNT 表现出更粗糙并抑制 MSC 的增殖。TNT 表现出亲水表面和细胞功能的平衡促进。在植入兔股骨模型后，TNT 显示出最佳的成骨诱导能力以及与基底的强结合强度。这些结果表明，与微和混合微/纳米表面相比，纳米级 TNT 为改善植入物的临床性能提供了有利的表面形貌，为钛植入物的临床应用提供了一种有前途且可靠的表面改性策略。
