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TGA转录因子——作为功能变异性基础的结构特征

TGA transcription factors-Structural characteristics as basis for functional variability.

作者信息

Tomaž Špela, Gruden Kristina, Coll Anna

机构信息

Department of Biotechnology and Systems Biology, National Institute of Biology, Ljubljana, Slovenia.

Jožef Stefan International Postgraduate School, Ljubljana, Slovenia.

出版信息

Front Plant Sci. 2022 Jul 26;13:935819. doi: 10.3389/fpls.2022.935819. eCollection 2022.

DOI:10.3389/fpls.2022.935819
PMID:35958211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9360754/
Abstract

TGA transcription factors are essential regulators of various cellular processes, their activity connected to different hormonal pathways, interacting proteins and regulatory elements. Belonging to the basic region leucine zipper (bZIP) family, TGAs operate by binding to their target DNA sequence as dimers through a conserved bZIP domain. Despite sharing the core DNA-binding sequence, the TGA paralogues exert somewhat different DNA-binding preferences. Sequence variability of their N- and C-terminal protein parts indicates their importance in defining TGA functional specificity through interactions with diverse proteins, affecting their DNA-binding properties. In this review, we provide a short and concise summary on plant TGA transcription factors from a structural point of view, including the relation of their structural characteristics to their functional roles in transcription regulation.

摘要

TGA转录因子是各种细胞过程的关键调节因子，其活性与不同的激素途径、相互作用蛋白和调控元件相关。TGA属于碱性区域亮氨酸拉链（bZIP）家族，通过一个保守的bZIP结构域以二聚体形式结合其靶DNA序列来发挥作用。尽管TGA同源物共享核心DNA结合序列，但它们表现出略有不同的DNA结合偏好。其N端和C端蛋白质部分的序列变异性表明，它们通过与多种蛋白质相互作用来定义TGA功能特异性，从而影响其DNA结合特性，这一点很重要。在本综述中，我们从结构角度对植物TGA转录因子进行了简短而精炼的总结，包括它们的结构特征与其在转录调控中的功能作用之间的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/885b/9360754/55961c64b319/fpls-13-935819-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/885b/9360754/456b2130b9e7/fpls-13-935819-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/885b/9360754/ae9225d519b5/fpls-13-935819-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/885b/9360754/c7adb961c14e/fpls-13-935819-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/885b/9360754/55961c64b319/fpls-13-935819-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/885b/9360754/456b2130b9e7/fpls-13-935819-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/885b/9360754/ae9225d519b5/fpls-13-935819-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/885b/9360754/c7adb961c14e/fpls-13-935819-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/885b/9360754/55961c64b319/fpls-13-935819-g004.jpg

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