Lee Ye Li, Lee Sang Yeoup
Integrated Research Institute for Natural Ingredients and Functional Foods, Yangsan, South Korea.
Family Medicine Clinic and Biomedical Research Institute, Pusan National University Yangsan Hospital, Yangsan, South Korea.
Front Nutr. 2022 Jul 25;9:935395. doi: 10.3389/fnut.2022.935395. eCollection 2022.
Oysters possess an excellent nutritional profile containing γ-aminobutyric acid (GABA). Previous data suggest that GABA is a potent bioactive compound for improving muscle health. Lactic acid fermentation is thought to increase GABA content. However, the effect of oral supplementation of fermented oyster extracts (FO) on human muscle strength and mass is unclear. Therefore, we tested the effects and safety of consumption of FO combined with regular walking for 12 weeks on muscle strength and mass in older adults with relatively low muscle mass.
A randomized controlled trial was conducted on 54 adults between 50 and 78 years of age. Participants were randomized to receive either placebo or 1,200 mg FO daily for 12 weeks. By fermentation with BJ20, FO was prepared from . At baseline and at 12 weeks after treatment, the following parameters of the participants were examined: knee strengths, handgrip strengths, body composition, blood tests, and 24-h dietary recall. All participants were required to walk for 30-60 min/day for >3 days/week during the trial period. Physical activity was assessed using an exercise log during the study.
Of the 54 participants, 49 completed the trial without reporting adverse effects. FO supplementation over 12 weeks did not cause any increase in knee or grip strength compared to the control group. Also, no differences were observed in the muscle mass, growth hormone, muscle biomarkers, anti-inflammatory markers, and antioxidative markers between the two groups. None of the participants experienced adverse events. Application of FO was well tolerated, and no notable adverse effect was reported in both groups.
FO supplementation with regular walking did not improve remarkably muscle function compared to regular walking alone in adults with relatively low muscle mass.
[www.ClinicalTrials.gov], identifier [NCT04109911].
牡蛎具有出色的营养成分，其中含有γ-氨基丁酸（GABA）。先前的数据表明，GABA是一种改善肌肉健康的强效生物活性化合物。乳酸发酵被认为会增加GABA含量。然而，口服补充发酵牡蛎提取物（FO）对人体肌肉力量和质量的影响尚不清楚。因此，我们测试了在肌肉质量相对较低的老年人中，食用FO并结合规律步行12周对肌肉力量和质量的影响及安全性。
对54名年龄在50至78岁之间 的成年人进行了一项随机对照试验参与者被随机分为两组，一组接受安慰剂，另一组每天接受1200毫克FO，为期12周。通过与BJ20发酵，从……制备了FO。在基线和治疗后12周时，对参与者的以下参数进行了检查：膝关节力量、握力、身体成分、血液检测和24小时饮食回顾。在试验期间，所有参与者都被要求每天步行30至60分钟，每周超过3天。在研究期间，使用运动日志评估身体活动情况。
54名参与者中，49名完成了试验，且未报告不良反应。与对照组相比，补充12周的FO并未导致膝关节或握力有任何增加。此外，两组之间在肌肉质量、生长激素、肌肉生物标志物、抗炎标志物和抗氧化标志物方面均未观察到差异。没有参与者经历不良事件。FO的应用耐受性良好，两组均未报告明显的不良反应。
在肌肉质量相对较低的成年人中，与单独规律步行相比，补充FO并结合规律步行并未显著改善肌肉功能。
[www.ClinicalTrials.gov]，标识符 [NCT04109911]。
