Filipski J
FEBS Lett. 1987 Jun 15;217(2):184-6. doi: 10.1016/0014-5793(87)80660-9.
The vertebrate genome is built of long DNA regions, relatively homogeneous in GC content, which likely correspond to bands on stained chromosomes. Large differences in composition have been found among DNA regions belonging to the same genome. They are paralleled by differences in codon usage in genes differently localized. The hypothesis presented here asserts that these differences in composition are caused by different mutational bias of alpha and beta DNA polymerases, these polymerases being involved to different extents in the repair of DNA lesions in compact and relaxed chromatin, respectively, in germline cells.
脊椎动物基因组由长DNA区域构成，其GC含量相对均匀，这些区域可能对应于染色染色体上的条带。在属于同一基因组的DNA区域之间发现了组成上的巨大差异。它们与不同定位基因中密码子使用的差异并行。这里提出的假说是，这些组成上的差异是由α和β DNA聚合酶不同的突变偏向性引起的，这些聚合酶分别在生殖细胞中紧密和松弛染色质的DNA损伤修复中发挥不同程度的作用。
