Xiao Zijie, Huang Guolin, Li Guanhong, Wang Huihui, Zheng Xiaoyu, Li Yongchun, Gong Fengying, Lv Ying, Li Jingjun
Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Front Cardiovasc Med. 2024 Apr 25;11:1344764. doi: 10.3389/fcvm.2024.1344764. eCollection 2024.
Several observational studies have shown that high-volume and high-intensity exercise training increases the prevalence and severity of coronary atherosclerosis, but the causal effect still remains uncertain. This study aims to explore the causal relationship between the volume of strenuous exercise (SE) and coronary atherosclerosis (CA) using the Mendelian randomization (MR) method.
The exposure factors were two basic parameters of the volume of strenuous exercise (duration and frequency of strenuous exercise), the outcome factor was coronary atherosclerosis, and the relevant genetic loci were extracted from the summary data of the genome-wide association study (GWAS) as the instrumental variables, and MR analyses were performed using the inverse variance weighting (IVW) method, the weighted median method, and the MR-egger method. Sensitivity analyses were performed using heterogeneity analysis, pleiotropy analysis, and the "leave-one-out" method. The original results were tested using other coronary atherosclerosis data sets.
IVW results showed no causal association between duration of strenuous exercise (DOSE) [OR = 0.9937, 95% CI (0.9847, 1.0028), = 0.1757] and frequency of strenuous exercise (FOSE) in the last 4 weeks [OR = 0.9930, 95% CI (0.9808, 1.0054), = 0.2660] and coronary atherosclerosis. All of the above results were validated with other coronary atherosclerosis data sets.
The present study supports that the causal association of duration and frequency of SE with CA was not found, and provides valuable insights into the choice of scientific and correct volume of SE to cardiac rehabilitation (CR).
多项观察性研究表明，大量高强度运动训练会增加冠状动脉粥样硬化的患病率和严重程度，但其因果关系仍不确定。本研究旨在使用孟德尔随机化（MR）方法探讨剧烈运动（SE）量与冠状动脉粥样硬化（CA）之间的因果关系。
暴露因素为剧烈运动的两个基本参数（剧烈运动的持续时间和频率），结局因素为冠状动脉粥样硬化，从全基因组关联研究（GWAS）的汇总数据中提取相关基因位点作为工具变量，并使用逆方差加权（IVW）法、加权中位数法和MR-egger法进行MR分析。使用异质性分析、多效性分析和“留一法”进行敏感性分析。使用其他冠状动脉粥样硬化数据集对原始结果进行检验。
IVW结果显示，剧烈运动持续时间（DOSE）[比值比（OR）=0.9937，95%置信区间（CI）（0.9847，1.0028），P=0.1757]和过去4周内剧烈运动频率（FOSE）[OR=0.9930，95%CI（0.9808，1.0054），P=0.2660]与冠状动脉粥样硬化之间无因果关联。上述所有结果均在其他冠状动脉粥样硬化数据集上得到验证。
本研究支持未发现SE的持续时间和频率与CA之间存在因果关联，并为心脏康复（CR）中科学正确的SE量选择提供了有价值的见解。
