Yang C P, Chow W H, Daling J R, Weiss N S, Moore D E
Fertil Steril. 1987 Jul;48(1):62-6.
One hundred forty-nine patients who underwent surgery for tubal pregnancy at five hospitals in Seattle (WA) between 1975 and 1979 were interviewed to determine the risk factors for this disorder. Their responses were compared with those of 706 control women who had conceived an intrauterine pregnancy during the same time period during which the tubal pregnancies occurred. A higher proportion of cases reported a history of infertility (attempt to conceive without success for a period of at least 1 year) than controls (relative risk [RR] = 2.5; 95% confidence interval [CI] = 1.7-3.7). Women who were diagnosed in the investigation of their infertility as having tubal or ovulatory dysfunction had relative risks of tubal pregnancy of 5.8 (95% CI = 2.1-16.4) and 3.4 (95% CI = 1.3-8.5), respectively. The average time over which subjects had attempted to conceive before index pregnancies that were planned was longer among cases (15.4 months) than among controls (6.9 months). These results support the hypothesis that a history of infertility predisposes women to an increased risk of tubal pregnancy. The authors also found that, among infertile women, about twice as many cases (14.3%) as controls (6.8%) were current fertility drug users (RR = 3.1; 95% CI = 1.1-9.1), which suggests that the use of fertility drug(s) may further increase the risk of tubal pregnancy.
1975年至1979年间，对在西雅图（华盛顿州）五家医院接受输卵管妊娠手术的149名患者进行了访谈，以确定该疾病的危险因素。将他们的回答与706名对照女性的回答进行了比较，这些对照女性在输卵管妊娠发生的同一时期内怀上了宫内妊娠。与对照组相比，报告有不孕史（至少1年未能成功受孕）的病例比例更高（相对风险[RR]=2.5；95%置信区间[CI]=1.7-3.7）。在不孕症检查中被诊断为输卵管或排卵功能障碍的女性，输卵管妊娠的相对风险分别为5.8（95%CI=2.1-16.4）和3.4（95%CI=1.3-8.5）。在计划的指数妊娠之前，病例组尝试受孕的平均时间（15.4个月）比对照组（6.9个月）更长。这些结果支持了不孕史会使女性输卵管妊娠风险增加的假设。作者还发现，在不孕女性中，使用促孕药物的病例（14.3%）约为对照组（6.8%）的两倍（RR=3.1；95%CI=1.1-9.1），这表明使用促孕药物可能会进一步增加输卵管妊娠的风险。
