Song Jing, Jin Chenye, Shan Zhongyan, Teng Weiping, Li Jing
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Beijing Key Laboratory of Diabetes Research and Care, Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital Capital Medical University, Beijing 101100, China.
J Transl Int Med. 2022 Jul 7;10(2):134-145. doi: 10.2478/jtim-2022-0031. eCollection 2022 Jun.
Hyperuricemia (HUA) and gout seriously influence patients' quality of life. The current study was performed to investigate the prevalence of HUA and gout and the related risk factors in Chinese adults.
Data were collected from the National Survey of Thyroid Disorders and Diabetes (the Thyroid Disease, Iodine Status, and Diabetes National Epidemiological survey [TIDE]), a cross-sectional investigation conducted during 2015-2017. Using a random, multistage, and stratified sampling strategy, a representative sample (78,130 participants aged 18 years and above) was selected from the general population in 31 provinces of mainland China. The weighted prevalence rates of HUA and gout were calculated, and the related risk factors were analyzed.
The weighted prevalence rates of HUA and gout in Chinese adults were 17.7% and 3.2%, respectively. The prevalence of HUA in males linearly decreased with age, while the prevalence in females showed the opposite trend (both for trend < 0.01). The prevalence rate of gout exhibited a rising tendency with age in both genders (both for trend < 0.05). The HUA and gout prevalence rates in males were the highest in Han and Tibetan nationalities, respectively. Logistic regression analysis showed that the morbidities of HUA and gout were differentially associated with age, residence location, nationality, smoking, and other complicating metabolic diseases in the two genders.
There are relatively high prevalence rates of gout and HUA in China, which is currently a developing country. Reducing their burden has become an urgent issue for Chinese people.
高尿酸血症（HUA）和痛风严重影响患者生活质量。本研究旨在调查中国成年人中HUA和痛风的患病率及其相关危险因素。
数据来自全国甲状腺疾病与糖尿病调查（甲状腺疾病、碘营养状况与糖尿病全国流行病学调查 [TIDE]），这是一项在2015 - 2017年期间开展的横断面调查。采用随机、多阶段、分层抽样策略，从中国大陆31个省份的普通人群中选取了一个具有代表性的样本（78,130名18岁及以上参与者）。计算HUA和痛风的加权患病率，并分析相关危险因素。
中国成年人中HUA和痛风的加权患病率分别为17.7%和3.2%。男性HUA患病率随年龄呈线性下降，而女性患病率呈现相反趋势（趋势检验P均<0.01）。痛风患病率在男女两性中均随年龄呈上升趋势（趋势检验P均<0.05）。男性中HUA患病率在汉族和藏族中最高，痛风患病率也在藏族中最高。Logistic回归分析显示，HUA和痛风的发病率在两性中与年龄、居住地点、民族、吸烟以及其他合并的代谢性疾病存在差异关联。
在中国这个目前的发展中国家，痛风和HUA的患病率相对较高。减轻其负担已成为中国民众的紧迫问题。
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