Department of Medicine, School of Medicine, Emory University, 1365 Clifton Rd, Atlanta, GA, A140030322, USA.
Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Biogerontology. 2022 Oct;23(5):615-627. doi: 10.1007/s10522-022-09985-8. Epub 2022 Aug 12.
Chronic stress is associated with deleterious health outcomes and mortality risk. A potential mechanism by which stress affects healthspan and lifespan is acceleration of cellular aging. Biologic age prediction models, termed epigenetic clocks, have been developed to estimate biologic age differences among people with the same chronologic age. This study evaluates the simultaneous impact of perceived chronic stress and resilience on Grim Age acceleration. The perceived stress score (PSS) and Connor-Davidson Resilience Scale (CD-RISC) were used to measure chronic stress and resilience, respectively. DNA was extracted from whole blood and analyzed using the MethylationEPIC BeadChip. GrimAge estimates were calculated using the methylation age calculator. Forty-seven business executives were categorized by levels of high or low stress and resilience scores. Compared to participants with low stress and high resilience, those with low stress and low resilience demonstrated the strongest association with Grim Age acceleration (p = 0.044), after controlling for age and estimated cellular proportions. Interestingly, among participants with low resilience, those with high perceived stress had a weaker association with Grim Age acceleration than participants with low perceived stress. However, among participants with high resilience, low perceived stress had a weaker association with Grim Age acceleration than high perceived stress. Our findings suggest that the impact of perceived stress on epigenetic age acceleration may differ based on resilience capacity, with a potential paradoxical beneficial effect among those with low resilience.
慢性压力与不良健康结果和死亡风险有关。压力影响健康寿命和寿命的一个潜在机制是加速细胞衰老。生物年龄预测模型，称为表观遗传时钟，已经被开发出来，以估计具有相同实际年龄的人群之间的生物年龄差异。本研究评估了感知慢性压力和韧性对 GrimAge 加速的同时影响。感知压力评分（PSS）和 Connor-Davidson 韧性量表（CD-RISC）分别用于测量慢性压力和韧性。从全血中提取 DNA 并使用 MethylationEPIC BeadChip 进行分析。使用甲基化年龄计算器计算 GrimAge 估计值。47 名企业高管根据高或低压力和韧性评分进行分类。与压力和韧性较低的参与者相比，在控制年龄和估计的细胞比例后，压力和韧性较低的参与者与 GrimAge 加速的相关性最强（p=0.044）。有趣的是，在韧性较低的参与者中，高感知压力与 GrimAge 加速的相关性弱于低感知压力的参与者。然而，在韧性较高的参与者中，低感知压力与 GrimAge 加速的相关性弱于高感知压力。我们的研究结果表明，感知压力对表观遗传年龄加速的影响可能因韧性能力而异，对于韧性较低的人来说，可能存在一种潜在的有益悖论。
