Kusters Cynthia D J, Horvath Steve
Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA; email:
Altos Labs, Cambridge, United Kingdom; email:
Annu Rev Public Health. 2025 Apr;46(1):91-110. doi: 10.1146/annurev-publhealth-060222-015657. Epub 2024 Dec 16.
Estimators of biological age hold promise for use in preventive medicine, for early detection of chronic conditions, and for monitoring the effectiveness of interventions aimed at improving population health. Among the promising biomarkers in this field are DNA methylation-based biomarkers, commonly referred to as epigenetic clocks. This review provides a survey of these clocks, with an emphasis on second-generation clocks that predict human morbidity and mortality. It explores the validity of epigenetic clocks when considering factors such as race, sex differences, lifestyle, and environmental influences. Furthermore, the review addresses the current challenges and limitations in this research area.
生物年龄估计器有望用于预防医学、慢性病的早期检测以及监测旨在改善人群健康的干预措施的有效性。该领域有前景的生物标志物包括基于DNA甲基化的生物标志物，通常称为表观遗传时钟。本综述对这些时钟进行了概述，重点关注预测人类发病率和死亡率的第二代时钟。它探讨了在考虑种族、性别差异、生活方式和环境影响等因素时表观遗传时钟的有效性。此外，该综述还讨论了这一研究领域当前面临的挑战和局限性。
