Du Mi, Xu Shulan, Qiu Bingjiang, Hu Shixian, Tjakkes Geerten-Has E, Li An, Ge Shaohua
School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration, Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China.
Center of Oral Implantology, Stomatological Hospital, Southern Medical University, Guangzhou, China.
J Periodontol. 2023 Feb;94(2):204-216. doi: 10.1002/JPER.22-0346. Epub 2022 Oct 27.
The association between periodontitis and allergic symptoms has been investigated. However, the difference in immune signatures between them remains poorly understood. This cross-sectional study assessed the relationship between serum immunoglobulin G (IgG) antibodies to periodontal pathogens and allergic symptoms in a nationwide population cohort.
Two phases of the Third National Health and Nutrition Examination Survey (NHANES III) were used as discovery dataset (n = 3700) and validation dataset (n = 4453), respectively. Based on the antibodies against 19 periodontal pathogens, we performed an unsupervised hierarchical clustering to categorize the population into three clusters. In the discovery dataset, cluster 1 (n = 2847) had the highest level of IgG antibodies, followed by clusters 2 (n = 588) and 3 (n = 265). Data on allergic symptoms (asthma, hay fever, and wheezing) were obtained using a self-reported questionnaire. Survey-weighted multivariable logistic regression evaluated the association between these clusters and allergic symptoms.
In the discovery dataset, the participants with lower levels of antibodies to periodontal pathogens exhibited a higher risk of asthma (odds ratio [OR] = 1.820, 95% confidence interval [CI]: 1.153-2.873) and wheezing (OR = 1.550, 95% CI: 1.095-2.194) compared to those with higher periodontal antibodies, but the non-significant association with hay fever. Consistent results were found in the validation dataset.
Serum IgG titers to periodontal pathogens were inversely associated with the risk of asthma and wheezing, suggesting the potentially protective role against allergic conditions.
牙周炎与过敏症状之间的关联已得到研究。然而，它们之间免疫特征的差异仍知之甚少。这项横断面研究评估了全国人群队列中针对牙周病原体的血清免疫球蛋白G（IgG）抗体与过敏症状之间的关系。
第三次全国健康与营养检查调查（NHANES III）的两个阶段分别用作发现数据集（n = 3700）和验证数据集（n = 4453）。基于针对19种牙周病原体的抗体，我们进行了无监督分层聚类，将人群分为三个簇。在发现数据集中，簇1（n = 2847）的IgG抗体水平最高，其次是簇2（n = 588）和簇3（n = 265）。使用自我报告问卷获取过敏症状（哮喘、花粉症和喘息）的数据。调查加权多变量逻辑回归评估了这些簇与过敏症状之间的关联。
在发现数据集中，与牙周抗体水平较高的参与者相比，牙周病原体抗体水平较低的参与者患哮喘（优势比[OR] = 1.820，95%置信区间[CI]：1.153 - 2.873）和喘息（OR = 1.550，95% CI：1.095 - 2.194）的风险更高，但与花粉症的关联不显著。在验证数据集中也发现了一致的结果。
针对牙周病原体的血清IgG滴度与哮喘和喘息风险呈负相关，表明对过敏状况可能具有保护作用。
