Department of Genetics, University of Bucharest, Intrarea Portocalelor 1-3, 060101, Bucharest, Romania.
Earth, Environmental and Life Sciences Division, The Research Institute of the University of Bucharest (ICUB), Bucharest, Romania.
Arch Virol. 2022 Nov;167(11):2311-2318. doi: 10.1007/s00705-022-05559-8. Epub 2022 Aug 13.
Torque teno virus (TTV) is highly prevalent, but little is known about its circulation in humans. Here, we investigated the geographical distribution and phylogeny of TTV in Romania. A fragment of TTV untranslated region B was sequenced in samples from volunteers across the country. Additional sequences from dialyzed patients were also included in the study. Phylogenetic analysis showed that more than 80% of Romanian sequences clustered with isolates assigned to the species Torque teno virus 1 and Torque teno virus 3 (former genogroup 1), and this analysis discriminated between isolates from the North-East and West regions. Further studies assessing the pathogenic potential of TTV isolates should employ analysis based on genomic regions with phylogenetic resolution below the species level.
扭结瘤病毒（TTV）的感染率很高，但人类对其传播情况知之甚少。在这里，我们研究了罗马尼亚 TTV 的地理分布和系统发育。对来自全国各地志愿者的样本进行了 TTV 非翻译区 B 片段的测序。研究中还包括来自透析患者的额外序列。系统发育分析表明，罗马尼亚的 80%以上的序列与归属于 1 型和 3 型扭结瘤病毒（原基因 1 组）的分离株聚类，这一分析区分了来自东北和西部地区的分离株。进一步研究 TTV 分离株的致病潜力时，应该采用基于种以下具有系统发育分辨率的基因组区域的分析。
