使用1.25%盐酸毛果芸香碱眼药水治疗老花眼后发生的孔源性视网膜脱离。
RHEGMATOGENOUS RETINAL DETACHMENT AFTER INITIATION OF PILOCARPINE HYDROCHLORIDE OPHTHALMIC SOLUTION 1.25% FOR TREATMENT OF PRESBYOPIA.
作者信息
Eton Emily A, Zhao Peter Y, Johnson Mark W, Rao Rajesh C, Huvard Michael J
机构信息
Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor, Michigan.
Department of Pathology, University of Michigan, Ann Arbor, Michigan.
出版信息
Retin Cases Brief Rep. 2024 Jan 1;18(1):98-100. doi: 10.1097/ICB.0000000000001309.
BACKGROUND/PURPOSE: Retinal detachment has previously been reported in association with topical miotic use for the treatment of glaucoma. Pilocarpine hydrochloride 1.25% was recently approved by the Food and Drug Administration for the treatment of presbyopia, with no reports of associated retinal detachments in the clinical trial data.
METHODS
Case report.
RESULTS
Two novel cases of unilateral retinal detachment occurring within 10 days of the initiation of pilocarpine 1.25% for the treatment of presbyopia were described. The patients were pseudophakic men in their 60s or 70s with preexisting retinal detachment risk factors, such as high myopia, lattice degeneration, and prior retinal detachment. Both affected eyes were treated with pars plana vitrectomy and gas endotamponade with an uncomplicated postoperative course.
CONCLUSION
Retinal detachment may be associated with the use of pilocarpine 1.25%. Caution should be used when considering prescribing this medication in patients with preexisting retinal abnormality.
背景/目的：此前有报道称视网膜脱离与用于治疗青光眼的局部缩瞳剂的使用有关。1.25%的盐酸毛果芸香碱最近被美国食品药品监督管理局批准用于治疗老花眼，在临床试验数据中没有相关视网膜脱离的报告。
方法
病例报告。
结果
描述了2例在开始使用1.25%毛果芸香碱治疗老花眼后10天内发生单侧视网膜脱离的新病例。患者为60多岁或70多岁的人工晶状体植入男性，存在视网膜脱离的危险因素，如高度近视、格子样变性和既往视网膜脱离。两只患眼均接受了玻璃体切除术和平坦部气体填充，术后过程顺利。
结论
视网膜脱离可能与1.25%毛果芸香碱的使用有关。对于已有视网膜异常的患者，在考虑开具此药物时应谨慎。
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