Department of Electrical Engineering & Computer Science, 4418 Engineering Hall, The University of California, Irvine, USA; Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India.
Centre for Nano-Biosensors, Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical And Technical Sciences, Poonamallee High Road, Velappanchavadi, Chennai 600077, Tamil Nadu, India.
J Hazard Mater. 2022 Oct 15;440:129705. doi: 10.1016/j.jhazmat.2022.129705. Epub 2022 Aug 3.
The quantitative analysis of neurological drugs is critical since the kinetics of body fluids is strongly dependent on the dosage of the drug levels. Thus, the study of neurological medicines is significant because of the major diseases connected to it, for instance, Alzheimer's and Parkinson's diseases. Herein, a 2D hybrid MXene/graphene (MX/Gr) film was synthesized through a top-down approach and utilized to prepare an electrochemical transducer for the electrochemical sensing of nicotine. The X-ray diffraction (XRD), Raman and X-ray photoelectron spectroscopy (XPS) confirmed the successful incorporation of MX with Gr sheets. The high-resolution scanning electron microscopy (HR-SEM) and transmission electron microscopy (TEM) have been used to confirm the formation of MX, graphene sheets and the MX/Gr hybrid film. Furthermore, the MX/Gr hybrid film composite modified glassy carbon electrode (GCE) was prepared to selectively detect the nicotine in phosphate buffer medium (0.1 M PBS, pH~7.4). Under the optimized condition, the MX/Gr/GCE based sensor provided a linear response against nicotine from 1 to 55 µM and 30 nM - 600 nM with the lowest limit of detections (LOD) of 290 nM and 0.28 nM by differential pulse voltammetry (DPV) and amperometry, respectively. This newly developed MX/Gr hybrid film modified electrode displayed a remarkable selectivity, sensitivity, and reproducibility for accurate detection of nicotine. Finally, this new sensor was applied to detect nicotine in human/artificial saliva samples with high accuracy.
由于体液动力学强烈依赖于药物水平的剂量，因此对神经药物进行定量分析至关重要。因此，由于与它相关的主要疾病，如阿尔茨海默病和帕金森病，对神经药物的研究意义重大。在此，通过自上而下的方法合成了二维混合 MXene/石墨烯（MX/Gr）薄膜，并将其用于制备用于电化学检测尼古丁的电化学传感器。X 射线衍射（XRD）、拉曼和 X 射线光电子能谱（XPS）证实了 MX 与 Gr 片的成功结合。高分辨率扫描电子显微镜（HR-SEM）和透射电子显微镜（TEM）用于证实 MX、石墨烯片和 MX/Gr 混合膜的形成。此外，制备了 MX/Gr 混合膜复合修饰玻碳电极（GCE）以在磷酸盐缓冲介质（0.1 M PBS，pH~7.4）中选择性检测尼古丁。在优化条件下，基于 MX/Gr/GCE 的传感器通过差分脉冲伏安法（DPV）和安培法分别对 1 至 55 µM 和 30 nM - 600 nM 的尼古丁提供线性响应，其检测限（LOD）分别低至 290 nM 和 0.28 nM。这种新开发的 MX/Gr 混合薄膜修饰电极对尼古丁的检测表现出显著的选择性、灵敏度和重现性，可实现尼古丁的精确检测。最后，该新型传感器用于检测人/人工唾液样本中的尼古丁，具有很高的准确性。
