Davis J W, Shelton L, Eigenberg D A, Hignite C E
Haemostasis. 1987;17(1-2):66-9. doi: 10.1159/000215560.
A random-order, double-blind crossover study was done to compare the effects of placebo and two different doses of aspirin on the endothelial cell count of venous blood before and after smoking. Each of 17 male habitual smokers with coronary artery disease smoked two cigarettes during each of three 20-min periods separated by 2 weeks. Each patient was asked to take a tablet containing 150 mg of aspirin, 300 mg of aspirin or a placebo 12 h before each experimental smoking period and to abstain from smoking in the interim. Endothelial cell counts were determined by means of differential centrifugation and phase-contrast microscopy and nicotine by gas chromatography. After ingestion of placebo, the mean endothelial cell counts (+/- SD) were 2.7 +/- 0.8 and 4.5 +/- 0.9 per counting chamber before and after smoking respectively (p less than 0.001). Endothelial cell counts and plasma nicotine concentrations were not significantly correlated. Neither the mean presmoking values nor smoking-induced changes in either variable were affected either dose of aspirin. The data suggest that smoking caused acute endothelial cell desquamation which was not prevented by aspirin.
进行了一项随机顺序、双盲交叉研究，以比较安慰剂和两种不同剂量阿司匹林对吸烟前后静脉血内皮细胞计数的影响。17名患有冠状动脉疾病的男性习惯性吸烟者，在三个间隔2周的20分钟时间段内，每个时间段吸两支烟。要求每位患者在每个实验吸烟期前12小时服用一片含150毫克阿司匹林、300毫克阿司匹林或安慰剂的药片，并在此期间戒烟。通过差速离心和相差显微镜确定内皮细胞计数，通过气相色谱法测定尼古丁含量。服用安慰剂后，每个计数室吸烟前后的平均内皮细胞计数（±标准差）分别为2.7±0.8和4.5±0.9（p<0.001）。内皮细胞计数与血浆尼古丁浓度无显著相关性。两种剂量的阿司匹林均未影响吸烟前的平均数值或任一变量中吸烟引起的变化。数据表明，吸烟导致急性内皮细胞脱落，阿司匹林无法预防这种情况。
