Sinzinger H, Rauscha F, Fitscha P, Kaliman J
Atherosclerosis Research Group, Vienna, Austria.
Basic Res Cardiol. 1988 Nov-Dec;83(6):597-601. doi: 10.1007/BF01906953.
Endothelial damage is an early event in atherogenesis. Recent data present evidence that the counting of circulating endothelial cells in human peripheral blood may provide reliable information about endothelial integrity. We therefore assessed the influence of PGI2 on the number of circulating endothelial cells in patients suffering from peripheral vascular disease. As cigarette smokers and patients with hyperlipoproteinemia show an increased number of circulating endothelial cells, they were excluded from this investigation. PGI2 causes a certain drop in circulating endothelial cells. In parallel, a prolongation in platelet half-life can be noted. This is most pronounced at a daily duration of infusion between 4 an 12 h. A shorter duration of PGI2 therapy is less effective in reducing circulating endothelial cells. All of the three different doses used, however, were equally effective. Placebo controls were ineffective. These findings indicate that PGI2 might exert a rather long-lasting beneficial action on endothelial integrity and the hemostatic balance.
内皮损伤是动脉粥样硬化形成过程中的早期事件。最近的数据表明，计数人类外周血中循环内皮细胞的数量可能会提供有关内皮完整性的可靠信息。因此，我们评估了前列环素（PGI2）对患有外周血管疾病患者循环内皮细胞数量的影响。由于吸烟者和高脂蛋白血症患者的循环内皮细胞数量增加，故将他们排除在本研究之外。PGI2会使循环内皮细胞数量出现一定程度的下降。与此同时，可以注意到血小板半衰期延长。这在每日输注持续时间为4至12小时时最为明显。较短时间的PGI2治疗在减少循环内皮细胞方面效果较差。然而，所使用的三种不同剂量均具有同等效果。安慰剂对照则无效。这些发现表明，PGI2可能对内皮完整性和止血平衡发挥相当持久的有益作用。
