Davis J W, Shelton L, Eigenberg D A, Hignite C E, Watanabe I S
Clin Pharmacol Ther. 1985 May;37(5):529-33. doi: 10.1038/clpt.1985.83.
Endothelial damage and platelet activation may mediate increased cardiovascular morbidity and mortality in tobacco cigarette smokers. Our study was designed to determine whether acute effects of tobacco smoking on endothelium and platelets could be avoided by the substitution of non-tobacco cigarettes. Twenty healthy nonsmokers smoked two tobacco cigarettes in 20 minutes and on another occasion (separated by 1 week) smoked two cigarettes made from wheat, cocoa, and citrus plants. Mean endothelial cell counts from venous blood before and after smoking tobacco cigarettes were 2.3 and 4.8 and before and after smoking non-tobacco cigarettes counts were 2.5 and 3.0. Mean platelet aggregate ratios before and after smoking tobacco cigarettes were 0.80 and 0.65 and before and after smoking non-tobacco cigarettes they were 0.81 and 0.78. Much greater effects of tobacco smoking on endothelial cell counts and platelet aggregate ratios suggest the possibility that non-tobacco cigarette smoking may be less harmful to the cardiovascular system than is tobacco cigarette smoking.
内皮损伤和血小板活化可能介导吸烟人群心血管疾病发病率和死亡率的增加。我们的研究旨在确定用无烟香烟替代是否可以避免吸烟对内皮和血小板的急性影响。20名健康非吸烟者在20分钟内吸两支烟草香烟，在另一个场合（间隔1周）吸两支由小麦、可可和柑橘植物制成的香烟。吸烟草香烟前后静脉血中的平均内皮细胞计数分别为2.3和4.8，吸无烟香烟前后的计数分别为2.5和3.0。吸烟草香烟前后的平均血小板聚集率分别为0.80和0.65，吸无烟香烟前后分别为0.81和0.78。吸烟对内皮细胞计数和血小板聚集率的影响要大得多，这表明无烟香烟吸烟对心血管系统的危害可能比烟草香烟吸烟小。
