School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
International School of Public Health and One Health, Hainan Medical University, Haikou, 570100, People's Republic of China.
BMC Infect Dis. 2022 Aug 13;22(1):689. doi: 10.1186/s12879-022-07671-1.
Inappropriate use of antibiotics could have a profound negative impact on individual and community. This study aimed to assess the prevalence of inappropriate use behaviors of antibiotics in Chinese antibiotic users and explored their related factors.
A cross-sectional survey was conducted from July 1, 2018 to September 30, 2018. A structured questionnaire was widely distributed on the online survey platform (Questionnaire Star, https://www.wjx.cn ) and was used to collect data from respondents in China on demographic and sociological characteristics, antibiotic use and related knowledge. Main outcomes included self-medication with antibiotics (SMA), self-storage with antibiotics (SSA), and non-adherence to antibiotic treatment (NAAT). Logistic regression was used to identify the related factors of above inappropriate use behaviors of antibiotics.
Of the 15,526 participants, 37.1% reported SMA in the past 6 months, 67.9% reported SSA in the past 6 months, and 48.3%, 15.2%, 25.5% and 78.0% of respondents said that they had missed antibiotics, increased antibiotic dosage, decreased antibiotic dosage, and discontinued antibiotics once symptoms disappear, respectively. Overall, 53.3% reported NAAT during this period. After adjusting for other variables, multivariate logistic regression analyses showed that those aged 30-44 years old, with higher levels of education, poorer status of self-perceived health, or lower levels of antibiotic knowledge were more likely to have these inappropriate use behaviors of SMA, SSA, and NAAT (P < 0.05).
The prevalence of SMA, SSA, and NAAT is high in China. Developing a nationwide action plan for the rational use of antibiotics among publics, including national media publicity, online and offline health education, and medication guidance from general practitioners, is urgently needed.
抗生素的不恰当使用会对个人和社区产生深远的负面影响。本研究旨在评估中国抗生素使用者中抗生素不恰当使用行为的流行情况，并探讨其相关因素。
本研究采用横断面调查方法，于 2018 年 7 月 1 日至 9 月 30 日在中国通过在线调查平台（问卷星，https://www.wjx.cn）广泛发放调查问卷，收集受访者的人口统计学和社会学特征、抗生素使用情况和相关知识等数据。主要结局包括自行使用抗生素（SMA）、自行储存抗生素（SSA）和不遵医嘱使用抗生素（NAAT）。采用 Logistic 回归分析识别抗生素不恰当使用行为的相关因素。
在 15526 名参与者中，37.1%的人在过去 6 个月内有 SMA，67.9%的人在过去 6 个月内有 SSA，48.3%、15.2%、25.5%和 78.0%的受访者表示他们曾漏用、增加、减少或停止使用抗生素，直至症状消失。总体而言，53.3%的人在这段时间内有 NAAT。在调整其他变量后，多变量 Logistic 回归分析显示，年龄在 30-44 岁、受教育程度较高、自我健康状况较差或抗生素知识水平较低的人更有可能出现 SMA、SSA 和 NAAT 等不恰当使用行为（P<0.05）。
中国 SMA、SSA 和 NAAT 的流行率较高。迫切需要制定一项全国性的公众抗生素合理使用行动计划，包括国家媒体宣传、线上线下健康教育以及全科医生的用药指导。
