Ghafouri-Fard Soudeh, Noie Alamdari Ali, Noee Alamdari Yashar, Abak Atefe, Hussen Bashdar Mahmud, Taheri Mohammad, Jamali Elena
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Cancer Cell Int. 2022 Aug 13;22(1):254. doi: 10.1186/s12935-022-02676-x.
PI3K/AKT pathway is an important pathway in the carcinogenesis since it has central impacts in the regulation of metabolic pathways, cell proliferation and survival, gene expression and protein synthesis. This pathway has been reported to be dysregulated in several types of cancers. In the current review, we summarize the role of this signaling pathway in squamous cell carcinomas (SCCs) originated from different parts of body cervix, oral cavity, head and neck and skin. The data presented in the current review shows the impact of dysregulation of PI3K/AKT pathway in survival of patients with SCC. Moreover, targeted therapies against this pathway have been found to be effective in reduction of tumor burden both in animal models and clinical settings. Finally, a number of molecules that regulate PI3K/AKT pathway can be used as diagnostic markers for different types of SCCs.
PI3K/AKT通路是癌症发生过程中的一条重要通路，因为它在代谢途径、细胞增殖与存活、基因表达和蛋白质合成的调节中具有核心作用。据报道，该通路在多种类型的癌症中存在失调。在本综述中，我们总结了这条信号通路在源自身体不同部位（子宫颈、口腔、头颈部和皮肤）的鳞状细胞癌（SCC）中的作用。本综述中呈现的数据显示了PI3K/AKT通路失调对SCC患者生存的影响。此外，已发现针对该通路的靶向治疗在动物模型和临床环境中均能有效减轻肿瘤负担。最后，一些调节PI3K/AKT通路的分子可作为不同类型SCC的诊断标志物。
