Yang Shiyi, Wen Luyao, Chai Xuyang, Song Yuanyuan, Chen Xin, Chen Zhi-Feng, Li Ruijin, Dong Chuan, Qi Zenghua, Cai Zongwei
Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, China.
State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China.
Sci Total Environ. 2022 Dec 10;851(Pt 1):157966. doi: 10.1016/j.scitotenv.2022.157966. Epub 2022 Aug 12.
As it is nearly impossible to reduce PM concentrations in most cities to safe limits in a short period of time, dietary supplementation presents a promising approach for mitigating the adverse effects of PM exposure. A cross-sectional study showed that the elderly population of Linfen (PM: 102 μg/m) exhibited significantly lower serum taurine levels, as well as higher oxidative stress levels and cardiovascular health risks, than the corresponding population in Guangzhou (PM: 39 μg/m). We conducted a random double-blind study on aged mice that employed a "real-world" PM exposure system to simulate the conditions of Linfen with the aim of investigating the protective effects of taurine and fish oil supplementation on PM-induced heart dysfunction. When compared with the placebo group, supplementation with taurine and fish oil not only maintained normal taurine levels, but also suppressed oxidative stress and inflammation in aged mice subjected to high concentrations of PM. Variations in heart rate, contractile function, cardiac oxidative stress, inflammation and fibrosis among different groups of aged mice were used to clarify the beneficial effects of taurine and fish oil supplementation. Our results not only revealed the protective effects of taurine and fish oil supplementation on heart dysfunction induced by PM exposure from the aged mice experiments and also provided new means for the elderly to resist PM pollution at the individual level.
由于在短时间内将大多数城市的颗粒物（PM）浓度降低到安全限值几乎是不可能的，膳食补充剂为减轻PM暴露的不良影响提供了一种有前景的方法。一项横断面研究表明，临汾（PM：102μg/m³）的老年人群血清牛磺酸水平显著低于广州（PM：39μg/m³）的相应人群，氧化应激水平和心血管健康风险也更高。我们对老年小鼠进行了一项随机双盲研究，采用“真实世界”的PM暴露系统模拟临汾的情况，旨在研究补充牛磺酸和鱼油对PM诱导的心脏功能障碍的保护作用。与安慰剂组相比，补充牛磺酸和鱼油不仅维持了正常的牛磺酸水平，还抑制了高浓度PM暴露的老年小鼠的氧化应激和炎症。通过不同组老年小鼠的心率、收缩功能、心脏氧化应激、炎症和纤维化的变化来阐明补充牛磺酸和鱼油的有益作用。我们的研究结果不仅从老年小鼠实验中揭示了补充牛磺酸和鱼油对PM暴露诱导的心脏功能障碍的保护作用，还为老年人在个体层面抵抗PM污染提供了新手段。
