使用磷光纳米探针在 FLASH 放疗过程中的实时光学血氧测定法。
Real-time optical oximetry during FLASH radiotherapy using a phosphorescent nanoprobe.
机构信息
Department of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA.
出版信息
Radiother Oncol. 2022 Nov;176:239-243. doi: 10.1016/j.radonc.2022.08.011. Epub 2022 Aug 11.
Abstract
The rapid depletion of oxygen during irradiation at ultra-high dose rate calls for tissue oximeters capable of high temporal resolution. This study demonstrates a water-soluble phosphorescent nanoprobe and fiber-coupled instrument, which together are used to measure the kinetics of oxygen depletion at 200 Hz during irradiation of in vitro solutions.
摘要
在超高剂量率辐照过程中，氧气会迅速消耗，这就需要能够实现高时间分辨率的组织血氧计。本研究展示了一种水溶性磷光纳米探针和光纤耦合仪器，它们一起用于测量体外溶液辐照过程中 200Hz 时氧气消耗的动力学。
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