Dutrillaux B, Al Achkar W, Aledo R, Aurias A, Couturier J, Dutrillaux A M, Flüry-Herard A, Gerbault-Seureau M, Hoffschir F, Lamoliatte E
Hum Genet. 1987 Jul;76(3):244-7. doi: 10.1007/BF00283616.
The analysis of a sample of 100 isoacentric (IA) and isocentric (IC) chromosomes, which had originated from spontaneous or radiation-induced deletions in human lymphocytes, is reported. IC and also IA have a strong tendency to be formed after breakage in juxtacentromeric heterochromatin. When euchromatic regions are involved, the breaks are not distributed at random since they frequently occur at places where juxtacentromeric heterochromatin exists in other primate species. It is assumed that intercalary structures conserving some of the properties of heterochromatin exists in human chromosomes in intercalary positions.
报道了对100条等臂中心（IA）和等中心（IC）染色体样本的分析，这些染色体源自人类淋巴细胞中的自发或辐射诱导缺失。IC以及IA在近着丝粒异染色质断裂后有很强的形成倾向。当常染色质区域涉及其中时，断裂并非随机分布，因为它们经常发生在其他灵长类物种中存在近着丝粒异染色质的位置。据推测，在人类染色体的居间位置存在保留一些异染色质特性的居间结构。
