某些药用植物甲醇提取物对糖尿病大鼠伤口愈合的功效

Efficacy of methanolic extracts of some medicinal plants on wound healing in diabetic rats.

作者信息

Alsarayreh Ahmad Z, Oran Sawsan A, Shakhanbeh Jumah M, Khleifat Khaled M, Al Qaisi Yaseen T, Alfarrayeh Ibrahim I, Alkaramseh Ayah M

机构信息

Department of Biological Sciences, Faculty of Sciences, Mutah University, Al-Karak, Jordan.

Department of Biological Sciences, Faculty of Sciences, University of Jordan, Amman, Jordan.

出版信息

Heliyon. 2022 Aug 2;8(8):e10071. doi: 10.1016/j.heliyon.2022.e10071. eCollection 2022 Aug.

BACKGROUND

One of the primary health concerns for diabetes individuals is wounds. The used drugs have several side effects, urging the need for new natural sources for therapeutics.

MATERIALS AND METHODS

This study was designed to estimate the wound healing potential of the methanolic extract of and leaves and fruits. plant extracts were orally administered to the rats to determine their effect on the wound-healing process.

RESULTS

Plant extracts significantly increased the contraction of the wound in non-diabetic and diabetic rats (P < 0.05) and increased the fibroblast's proliferation and migration resulting in a faster healing process. The plant extracts have no cytotoxic effects. The proliferation assay exhibited the lowest cell mortality after treatment with plant extract.

CONCLUSION

These findings may indicate that the methanolic leaf extract of the above plants can be used as new therapeutics for wound healing in diabetic patients.