某些药用植物甲醇提取物对糖尿病大鼠伤口愈合的功效
Efficacy of methanolic extracts of some medicinal plants on wound healing in diabetic rats.
作者信息
Alsarayreh Ahmad Z, Oran Sawsan A, Shakhanbeh Jumah M, Khleifat Khaled M, Al Qaisi Yaseen T, Alfarrayeh Ibrahim I, Alkaramseh Ayah M
机构信息
Department of Biological Sciences, Faculty of Sciences, Mutah University, Al-Karak, Jordan.
Department of Biological Sciences, Faculty of Sciences, University of Jordan, Amman, Jordan.
出版信息
Heliyon. 2022 Aug 2;8(8):e10071. doi: 10.1016/j.heliyon.2022.e10071. eCollection 2022 Aug.
BACKGROUND
One of the primary health concerns for diabetes individuals is wounds. The used drugs have several side effects, urging the need for new natural sources for therapeutics.
MATERIALS AND METHODS
This study was designed to estimate the wound healing potential of the methanolic extract of and leaves and fruits. plant extracts were orally administered to the rats to determine their effect on the wound-healing process.
RESULTS
Plant extracts significantly increased the contraction of the wound in non-diabetic and diabetic rats (P < 0.05) and increased the fibroblast's proliferation and migration resulting in a faster healing process. The plant extracts have no cytotoxic effects. The proliferation assay exhibited the lowest cell mortality after treatment with plant extract.
CONCLUSION
These findings may indicate that the methanolic leaf extract of the above plants can be used as new therapeutics for wound healing in diabetic patients.
背景
糖尿病患者主要的健康问题之一是伤口。现有药物有多种副作用，因此迫切需要新的天然治疗来源。
材料与方法
本研究旨在评估[植物名称]叶和果实的甲醇提取物的伤口愈合潜力。给大鼠口服植物提取物，以确定其对伤口愈合过程的影响。
结果
植物提取物显著增加了非糖尿病和糖尿病大鼠伤口的收缩（P < 0.05），并增加了成纤维细胞的增殖和迁移，从而加快了愈合过程。植物提取物无细胞毒性作用。增殖试验显示，用植物提取物处理后细胞死亡率最低。
结论
这些发现可能表明，上述植物的甲醇叶提取物可作为糖尿病患者伤口愈合的新疗法。
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