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（桃儿七）乙醇提取物对糖尿病创面模型中高糖成纤维细胞增殖和迁移的调节作用。

The Modulatory Effect of an Ethanolic Extract of (Ten.) on the Proliferation and Migration of Hyperglycemic Fibroblasts in an Diabetic Wound Model.

机构信息

Nursing Department, Federal University of Santa Maria, Santa Maria, Brazil.

Federal University of Santa Maria, Santa Maria, Brazil.

出版信息

Oxid Med Cell Longev. 2024 Oct 8;2024:2812290. doi: 10.1155/2024/2812290. eCollection 2024.

DOI:10.1155/2024/2812290
PMID:39411276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11479783/
Abstract

Diabetes mellitus is associated with chronic wound-healing problems that significantly impact patients' quality of life and substantially increase expenditure on healthcare. Therefore, the identification of compounds that can aid healing is justified. (Ten.) has been used in folk medicine for curative purposes; however, the causal mechanisms underlying its healing effects remain to be elucidated. In this study, the effect of the ethanolic extract of was evaluated in an healing model using fibroblasts cultivated under normoglycemic and hyperglycemic environments. The extract was predominantly composed of phytol and exhibited genoprotective activity. Fibroblast migration attenuated the adverse effects of hyperglycemia, favoring cell proliferation. Collagen levels were significantly increased in ruptured fibroblasts under both standard and hyperglycemic environments. The phytogenomic effect of the extract on three genes related to extracellular matrix formation, maintenance, and degradation showed that increased the expression of genes related to matrix synthesis and maintenance in both normoglycemic and hyperglycemic individuals. Furthermore, it reduced the expression of genes related to matrix degradation. Overall, this is the first study to demonstrate the effectiveness of in wound healing, elucidating possible causal mechanisms that appear to be based on the genoprotective effect of this plant on the migratory and proliferative phases of the wound healing process; these effects are probably related to phytol, its main constituent.

摘要

糖尿病与慢性伤口愈合问题有关，这些问题严重影响患者的生活质量，并大幅增加医疗保健支出。因此，有理由寻找可以帮助愈合的化合物。 （Ten.）在民间医学中被用于治疗目的；然而，其愈合效果的因果机制仍有待阐明。在这项研究中，使用在正常血糖和高血糖环境下培养的成纤维细胞评估了 的乙醇提取物在 愈合模型中的作用。提取物主要由植醇组成，并表现出基因保护活性。成纤维细胞迁移减轻了高血糖的不利影响，有利于细胞增殖。胶原水平在标准和高血糖环境下破裂的成纤维细胞中均显著增加。提取物对与细胞外基质形成、维持和降解相关的三个基因的植基因组学效应表明， 在正常血糖和高血糖个体中均增加了与基质合成和维持相关的基因表达。此外，它降低了与基质降解相关的基因表达。总的来说，这是第一项证明 在伤口愈合中有效的研究，阐明了可能的因果机制，这些机制似乎基于该植物对伤口愈合过程中迁移和增殖阶段的基因保护作用；这些作用可能与植醇及其主要成分有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dcf/11479783/7da06b42442d/OMCL2024-2812290.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dcf/11479783/0c9c1e0f8e1f/OMCL2024-2812290.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dcf/11479783/c5ad91812a26/OMCL2024-2812290.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dcf/11479783/d8baf2ec226b/OMCL2024-2812290.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dcf/11479783/7da06b42442d/OMCL2024-2812290.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dcf/11479783/0c9c1e0f8e1f/OMCL2024-2812290.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dcf/11479783/3f6c7bbfb354/OMCL2024-2812290.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dcf/11479783/0a7f87ec70f7/OMCL2024-2812290.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dcf/11479783/1e8b9d295092/OMCL2024-2812290.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dcf/11479783/c5ad91812a26/OMCL2024-2812290.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dcf/11479783/d8baf2ec226b/OMCL2024-2812290.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dcf/11479783/7da06b42442d/OMCL2024-2812290.007.jpg

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