Stewart Tracy Murray, Holbert Cassandra E, Casero Robert A
Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
Immunometabolism (Cobham). 2022 Aug 5;4(3):e00002. doi: 10.1097/IN9.0000000000000002. eCollection 2022 Jul.
The awareness that polyamines play a critical role in immune system regulation and function is coming into focus as the biological systems and analytical tools necessary to evaluate their roles have become available. Puleston et al have recently demonstrated that polyamine metabolism plays a central role in helper T-cell lineage determination through the production of the translational cofactor hypusinated eIF5A and faithful epigenetic regulation through proper histone acetylation. Their findings add to the rapidly growing body of data implicating properly controlled polyamine metabolism as essential for a normally functioning immune system.
随着评估多胺作用所需的生物系统和分析工具的出现，多胺在免疫系统调节和功能中发挥关键作用这一认识正日益受到关注。普莱斯顿等人最近证明，多胺代谢通过产生翻译辅因子hypusinated eIF5A在辅助性T细胞谱系决定中起核心作用，并通过适当的组蛋白乙酰化实现忠实的表观遗传调控。他们的发现增加了迅速增长的数据量，这些数据表明，正常运转的免疫系统离不开受到适当控制的多胺代谢。
