以乙醇为溶剂获取富含 policosanol 的甘蔗蜡馏分：基于汉森溶解度理论的结果解读
Obtaining a Fraction of Sugarcane Wax Rich in Policosanol by Using Ethanol as Solvent: Results Interpretation through Hansen's Solubility Theory.
作者信息
Díaz de Los Ríos Manuel, Hernández Ramos Eduardo, González Canavaciolo Víctor, Vicente Murillo Roxana, Pérez Carrión Katherine, Zumalacarregui de Cárdenas Lourdes
机构信息
Instituto Cubano de Investigaciones de los Derivados de la caña de azúcar (ICIDCA), Vía Blanca 804, esq. C. Central, SMP, La Habana 11000, Cuba.
Centro Nacional de Investigaciones Científicas (CNIC), Avenida 25, Esquina 21-A, 15202, Cubanacán, Playa, La Habana CP 11600, Cuba.
出版信息
ACS Omega. 2022 Jul 29;7(31):27324-27333. doi: 10.1021/acsomega.2c02314. eCollection 2022 Aug 9.
Determination of the best condition for fractionation of degreased sugarcane wax for policosanol production using ethanol was investigated in this paper. The optimal conditions related to the dispersion time of wax in the solvent, ethanol degree, and solvent/wax ratio were 30 min, 90.03% v/v, and 14:1 v/w, respectively. The results were evaluated by measuring six response variables: higher fatty alcohol concentration, octacosanol concentration, impurity concentration (measured as α,β unsaturated aldehydes), yield, cost indicator, and the ratio of octacosanol vs other higher fatty alcohols (C30 + C32 + C34). Optimal extraction conditions were determined with the desirability function. The complexity of separation of the higher alcohols fraction from impurities, mainly α,β unsaturated aldehydes, is explained with the aid of Hansen's solubility parameters theory and its variation with temperature.
本文研究了使用乙醇对脱蜡甘蔗蜡进行分馏以生产 policosanol 的最佳条件。与蜡在溶剂中的分散时间、乙醇浓度和溶剂/蜡比相关的最佳条件分别为 30 分钟、90.03% v/v 和 14:1 v/w。通过测量六个响应变量来评估结果：高级脂肪醇浓度、二十八烷醇浓度、杂质浓度（以 α,β 不饱和醛衡量）、产率、成本指标以及二十八烷醇与其他高级脂肪醇（C30 + C32 + C34）的比例。利用期望函数确定了最佳提取条件。借助 Hansen 溶解度参数理论及其随温度的变化，解释了从杂质（主要是 α,β 不饱和醛）中分离高级醇馏分的复杂性。
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