丙泊酚或依托咪酯全身麻醉诱导对胃癌的影响：一项10年随访的回顾性队列研究
Effect of Propofol or Etomidate as General Anaesthesia Induction on Gastric Cancer: A Retrospective Cohort Study with 10 Years' Follow-Up.
作者信息
Lu Xianfu, Yu Yue, Wang Yan, Lyu Yi
机构信息
Department of Anesthesiology High Tech Branch, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
Department of Anesthesiology, Chaohu Hospital of Anhui Medical University, Hefei, People's Republic of China.
出版信息
Cancer Manag Res. 2022 Aug 8;14:2399-2407. doi: 10.2147/CMAR.S361052. eCollection 2022.
OBJECTIVE
The aim is to study the effect of intraoperative application of propofol and etomidate on the long-term prognosis of patients with gastric cancer at the same tumor stage.
METHODS
A total of 1018 patients who underwent radical gastric cancer surgery at the First Affiliated Hospital of Anhui Medical University from January 2010 to December 2010 were selected and divided into the propofol and etomidate groups according to the different anesthetic induction drugs.
RESULTS
Among 244 patients in TNM stage IIIA, survival times were 36.10 and 41.79 for etomidate and propofol, respectively, which were statistically different (p < 0.05). Among the 82 patients in TNM stage IIIC, survival times were 26.57 and 35.20 for etomidate and propofol, respectively, which were statistically different (p < 0.05).
CONCLUSION
In patients undergoing radical gastric cancer surgery, the application of propofol during induction of anaesthesia is more beneficial in improving the postoperative survival time compared to the application of etomidate at a specific TNM stage.
目的
研究术中应用丙泊酚和依托咪酯对相同肿瘤分期的胃癌患者长期预后的影响。
方法
选取2010年1月至2010年12月在安徽医科大学第一附属医院接受胃癌根治术的1018例患者，根据不同的麻醉诱导药物分为丙泊酚组和依托咪酯组。
结果
在244例TNM IIIA期患者中，依托咪酯组和丙泊酚组的生存时间分别为36.10和41.79，差异有统计学意义（p<0.05）。在82例TNM IIIC期患者中，依托咪酯组和丙泊酚组的生存时间分别为26.57和35.20，差异有统计学意义（p<0.05）。
结论
在接受胃癌根治术的患者中，在特定TNM分期下，与应用依托咪酯相比，麻醉诱导期应用丙泊酚更有利于提高术后生存时间。
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