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胃癌治疗进展。

Updates on Management of Gastric Cancer.

机构信息

Section of Gastrointestinal Surgical Oncology, Peritoneal Surface Malignancy Program, Division of Surgical Oncology, Johns Hopkins University, 600 N. Wolfe Street/Blalock 606, Baltimore, MD, 21287, USA.

Department of Surgery, Johns Hopkins Hospital, 600 N. Wolfe Street/Blalock 665, Baltimore, MD, 21287, USA.

出版信息

Curr Oncol Rep. 2019 Jun 24;21(8):67. doi: 10.1007/s11912-019-0820-4.

DOI:10.1007/s11912-019-0820-4
PMID:31236716
Abstract

PURPOSE OF REVIEW

Gastric adenocarcinoma is the fifth most common and the third most lethal cancer worldwide. Surgery is the only chance of cure, but recurrence is common, even with complete resection.

RECENT FINDINGS

Advances in diagnosis and staging, genomic classification, surgical resection and treatment of peritoneal disease, systemic chemotherapy and chemoradiation, and targeted and immune therapies have led to the current multidisciplinary approach to gastric adenocarcinoma. Treatment of gastric cancer is rapidly evolving in an effort to combat this challenging disease.

摘要

目的综述

胃腺癌是全球第五大常见癌症,也是第三大最致命癌症。手术是唯一的治愈机会,但即使完全切除,仍常复发。

最新发现

在诊断和分期、基因组分类、手术切除和治疗腹膜疾病、全身化疗和放化疗、靶向和免疫治疗方面的进展,使得当前对胃腺癌采用了多学科方法。为了攻克这一具有挑战性的疾病,胃癌的治疗正在迅速发展。

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本文引用的文献

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Maintenance avelumab versus continuation of first-line chemotherapy in gastric cancer: JAVELIN Gastric 100 study design.胃癌中avelumab 维持治疗对比一线化疗的延续:JAVELIN Gastric 100 研究设计。
Future Oncol. 2019 Feb;15(6):567-577. doi: 10.2217/fon-2018-0668. Epub 2018 Oct 31.
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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018:GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
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CheckMate-032 Study: Efficacy and Safety of Nivolumab and Nivolumab Plus Ipilimumab in Patients With Metastatic Esophagogastric Cancer.
细胞外囊泡来源的长链非编码RNA-GC1作为预测和监测胃癌患者免疫治疗结果的新型生物标志物。
BMC Med. 2025 Aug 27;23(1):499. doi: 10.1186/s12916-025-04270-0.
4
Meta_B cells: a computationally identified candidate immunosuppressive driver of gastric cancer metastasis revealed by single-cell analysis and machine learning.Meta_B细胞:通过单细胞分析和机器学习揭示的一种经计算鉴定的胃癌转移候选免疫抑制驱动因素
Discov Oncol. 2025 Aug 6;16(1):1485. doi: 10.1007/s12672-025-03356-8.
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Identification of key ferroptosis-related genes associated with the development of gastric cancer: Prognostic models, molecular mechanisms and potential treatment strategies.鉴定与胃癌发生发展相关的关键铁死亡相关基因:预后模型、分子机制及潜在治疗策略。
Oncol Lett. 2025 Jul 18;30(4):450. doi: 10.3892/ol.2025.15196. eCollection 2025 Oct.
6
Role of S-palmitoylation in digestive system diseases.S-棕榈酰化在消化系统疾病中的作用。
Cell Death Discov. 2025 Jul 18;11(1):331. doi: 10.1038/s41420-025-02629-z.
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FOXM1 upregulation, promotes immune escape in gastric cancer through activation of Notch signaling pathway.FOXM1上调通过激活Notch信号通路促进胃癌免疫逃逸。
Mol Cell Biochem. 2025 Jun 11. doi: 10.1007/s11010-025-05322-y.
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World J Gastrointest Oncol. 2025 May 15;17(5):104776. doi: 10.4251/wjgo.v17.i5.104776.
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Abdom Radiol (NY). 2025 Jun 7. doi: 10.1007/s00261-025-04988-8.
CheckMate-032 研究:纳武利尤单抗和纳武利尤单抗联合伊匹单抗治疗转移性胃食管交界部癌患者的疗效和安全性。
J Clin Oncol. 2018 Oct 1;36(28):2836-2844. doi: 10.1200/JCO.2017.76.6212. Epub 2018 Aug 15.
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Phase III, randomised trial of avelumab versus physician's choice of chemotherapy as third-line treatment of patients with advanced gastric or gastro-oesophageal junction cancer: primary analysis of JAVELIN Gastric 300.avelumab 对比医师选择的化疗作为晚期胃癌或胃食管结合部癌三线治疗的 III 期随机试验:JAVELIN Gastric 300 的主要分析结果
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