通过抗体诱导评估丙烯酸酯化学品的免疫原性。
Immunogenicity of acrylate chemicals as assessed by antibody induction.
作者信息
Bull J E, Henderson D C, Turk J L
出版信息
Int Arch Allergy Appl Immunol. 1987;83(3):310-4. doi: 10.1159/000234313.
The immunogenicities of two acrylate chemicals, trimethylolpropane triacrylate (TMPTA) and methyl acrylate (MeAc), and one related vinyl compound, 4-vinyl pyridine (4VP), were investigated by determining the in vivo induction of IgG antibodies in guinea pigs. The injection of the chemicals emulsified in Freund's complete adjuvant resulted in the induction of serum antibody responses against MeAc and 4VP but not TMPTA. However, antibody with anti-TMPTA activity was produced following immunization of guinea pigs with TMPTA conjugated to protein, which allowed comparisons to be made of the immunogenic structural features of the compounds.
通过测定豚鼠体内IgG抗体的诱导情况，研究了两种丙烯酸酯化学品三羟甲基丙烷三丙烯酸酯（TMPTA）和丙烯酸甲酯（MeAc）以及一种相关的乙烯基化合物4-乙烯基吡啶（4VP）的免疫原性。注射乳化于弗氏完全佐剂中的化学品可诱导针对MeAc和4VP的血清抗体反应，但不能诱导针对TMPTA的反应。然而，用与蛋白质偶联的TMPTA免疫豚鼠后可产生具有抗TMPTA活性的抗体，从而能够对这些化合物的免疫原性结构特征进行比较。
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