Chung C W, Giles A L
J Invest Dermatol. 1977 Apr;68(4):187-90. doi: 10.1111/1523-1747.ep12492663.
Guinea pigs could be strongly sensitized to methyl, ethyl, and n-butyl methacrylates in ethanol or olive oil by the topical route, or in saline by the intradermal route. For elicitation of skin reactons, topical challenge with the compounds in olive oil or intradermal challenge with saline as the solvent was neccessary. Topical challenge with the methacrylates in ethanol failed to elicit any allergic skin reactions because of their volatility. All sensitized animals responded strongly not only to the inducing methacrylate but also to the other methacrylates, showing that mutual cross-sensitivity had occurred. Since methyl methacrylate has been reported to be a potent sensitizer in humans, the guinea-pig model described here may be useful for screening products before marketing.
豚鼠可通过局部途径在乙醇或橄榄油中，或通过皮内途径在盐水中对甲基丙烯酸甲酯、乙酯和正丁酯产生强烈致敏。为引发皮肤反应，有必要用橄榄油中的化合物进行局部激发，或以盐水为溶剂进行皮内激发。由于甲基丙烯酸酯在乙醇中的挥发性，用其在乙醇中进行局部激发未能引发任何过敏性皮肤反应。所有致敏动物不仅对诱导性甲基丙烯酸酯有强烈反应，对其他甲基丙烯酸酯也有强烈反应，表明发生了相互交叉致敏。由于甲基丙烯酸甲酯已被报道在人类中是一种强效致敏剂，这里描述的豚鼠模型可能有助于在产品上市前进行筛选。
