Clemmensen S
Drug Chem Toxicol. 1984;7(6):527-40. doi: 10.3109/01480548409042817.
The cross-reaction patterns of selected acrylate and methacrylate esters were investigated using the guinea pig maximization test. Methacrylates were less potent sensitizers than acrylates. Cross-sensitization was found between (meth)acrylates with closely related core structures, most extensively between hydroxyethyl and hydroxypropyl congeners. The importance of considering not only the functional group but also the core structure when assessing potential interactions was emphasized as butanedioldiglycidylether, hexamethylenediisocyanate and hexanedioldiacrylate--all with linear 6-atom cores and different functional group--cross-reacted.
使用豚鼠最大化试验研究了选定的丙烯酸酯和甲基丙烯酸酯的交叉反应模式。甲基丙烯酸酯作为致敏剂的效力低于丙烯酸酯。在具有密切相关核心结构的（甲基）丙烯酸酯之间发现了交叉致敏现象，在羟乙基和羟丙基同系物之间最为广泛。强调了在评估潜在相互作用时不仅要考虑官能团，还要考虑核心结构的重要性，因为丁二醇二缩水甘油醚、六亚甲基二异氰酸酯和己二醇二丙烯酸酯——均具有线性6原子核心和不同官能团——会发生交叉反应。
