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用于修复受损大脑的干细胞疗法：五项原则

Stem Cell Therapy for Repair of the Injured Brain: Five Principles.

作者信息

Rust Ruslan, Tackenberg Christian

机构信息

Institute for Regenerative Medicine, University of Zurich, Schlieren, Switzerland.

Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.

出版信息

Neuroscientist. 2024 Feb;30(1):10-16. doi: 10.1177/10738584221110100. Epub 2022 Aug 13.

DOI:10.1177/10738584221110100
PMID:35968796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10822053/
Abstract

Cell therapy holds great promise for regenerative treatment of disease. Despite recent breakthroughs in clinical research, applications of cell therapies to the injured brain have not yielded the desired results. We pinpoint current limitations and suggest five principles to advance stem cell therapies for brain regeneration. While we focus on cell therapy for stroke, all principles also apply for other brain diseases.

摘要

细胞疗法在疾病的再生治疗方面具有巨大潜力。尽管临床研究最近取得了突破，但细胞疗法在脑损伤治疗中的应用尚未产生预期效果。我们明确了当前的局限性，并提出了五项原则以推进用于脑再生的干细胞疗法。虽然我们专注于中风的细胞治疗，但所有原则也适用于其他脑部疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a55/10822053/9743d194841f/10.1177_10738584221110100-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a55/10822053/9743d194841f/10.1177_10738584221110100-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a55/10822053/9743d194841f/10.1177_10738584221110100-fig1.jpg

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本文引用的文献

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Xeno-free induced pluripotent stem cell-derived neural progenitor cells for in vivo applications.无动物成分诱导多能干细胞衍生的神经祖细胞用于体内应用。
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