Department of Neurosurgery and Stanford Stroke Center, Stanford University School of Medicine, Stanford, CA 94305-5487, USA.
Neurobiol Dis. 2010 Feb;37(2):275-83. doi: 10.1016/j.nbd.2009.10.003. Epub 2009 Oct 12.
Stem cell transplantation has evolved as a promising experimental treatment approach for stroke. In this review, we address the major hurdles for successful translation from basic research into clinical applications and discuss possible strategies to overcome these issues. We summarize the results from present pre-clinical and clinical studies and focus on specific areas of current controversy and research: (i) the therapeutic time window for cell transplantation; (ii) the selection of patients likely to benefit from such a therapy; (iii) the optimal route of cell delivery to the ischemic brain; (iv) the most suitable cell types and sources; (v) the potential mechanisms of functional recovery after cell transplantation; and (vi) the development of imaging techniques to monitor cell therapy.
干细胞移植已发展成为一种有前途的实验性治疗中风的方法。在这篇综述中，我们探讨了将基础研究成功转化为临床应用的主要障碍，并讨论了克服这些问题的可能策略。我们总结了目前的临床前和临床研究的结果，并重点关注当前存在争议和研究的特定领域：（i）细胞移植的治疗时间窗；（ii）可能从这种治疗中受益的患者的选择；（iii）将细胞递送到缺血性大脑的最佳途径；（iv）最合适的细胞类型和来源；（v）细胞移植后功能恢复的潜在机制；以及（vi）开发成像技术来监测细胞治疗。
