Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY.
J Cell Biol. 2022 Sep 5;221(9). doi: 10.1083/jcb.202208015. Epub 2022 Aug 16.
Actin remodeling promotes B cell activation by enabling B cell antigen receptor clustering in the immune synapse. In the current issue of JCB, Droubi et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202112018) find that this process is initiated by the lipid phosphatase INPP5B, which shapes synaptic actin architecture by locally depleting phosphatidylinositol 4,5 bisphosphate.
肌动蛋白重塑通过在免疫突触中形成 B 细胞抗原受体簇来促进 B 细胞的激活。在本期的《细胞生物学杂志》中，Droubi 等人（2022. J. Cell Biol.https://doi.org/10.1083/jcb.202112018）发现，这一过程是由脂质磷酸酶 INPP5B 启动的，它通过局部耗竭磷脂酰肌醇 4,5 二磷酸来塑造突触肌动蛋白结构。
