Alder V A, Cringle S J, Brown M
Invest Ophthalmol Vis Sci. 1987 Jul;28(7):1078-85.
PO2 measurements have been made for the first time within the retina and vitreous of cat eyes to compare normal and photocoagulated areas. This was done to test the hypothesis that the observed beneficial effects of pan-retinal photocoagulation therapy in the treatment of retinal vascular diseases with an ischemic origin, may be due to more oxygen becoming available to the remaining functioning retina. A xenon arc photocoagulator was used to photocoagulate large areas of cat retinas served by one major set of vessels while leaving the remaining retina untouched. After 6 months an acute experiment was performed in which retinal and vitreal oxygen tension profiles were measured using oxygen-sensitive microelectrodes to compare PO2 profiles in normal and photocoagulated regions, for two ventilation conditions: air and 100% O2. The only differences in PO2 values were found for the 100% O2 breathing condition, where values within the retina and in the overlying vitreous were larger in photocoagulated areas. It is proposed that any differences in PO2 distribution which occur for air breathing are masked by the autoregulatory capacity of the retinal circulation and the PO2 buffering capacity of hemoglobin.
首次在猫眼的视网膜和玻璃体内进行了氧分压（PO2）测量，以比较正常区域和光凝区域。这样做是为了检验以下假设：在治疗缺血性视网膜血管疾病时，全视网膜光凝疗法所观察到的有益效果可能是由于更多的氧气供应给了剩余的功能正常的视网膜。使用氙弧光凝器对由一组主要血管供应的大面积猫视网膜进行光凝，而其余视网膜保持未受影响。6个月后进行了一项急性实验，其中使用氧敏感微电极测量视网膜和玻璃体的氧张力分布，以比较在空气和100%氧气这两种通气条件下正常区域和光凝区域的PO2分布。仅在100%氧气呼吸条件下发现了PO2值的差异，此时光凝区域内视网膜和上方玻璃体内的值更大。有人提出，对于空气呼吸而言，PO2分布的任何差异都被视网膜循环的自动调节能力和血红蛋白的PO2缓冲能力所掩盖。
